Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 2022
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- A modified version of flask method indicated in OECD 107 was used as the substance is an UVCB.
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- A modified version of flask method indicated in OECD 107 was used as the substance is an UVCB.
- Deviations:
- yes
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch number: 3210640070
- Analytical method:
- liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= -1.97 - <= 1.17
- Temp.:
- 20 °C
- pH:
- ca. 7
- Details on results:
- Octanol/water partition varies with amount of test material used and it’s comprised between -1.97 and -1.17 at ambient temperature.
- Conclusions:
- Octanol/water partition coefficient of the test material is comprised between -1.97 and -1.17 at ambient temperature.
- Executive summary:
The test methods EC A.8 and OECD 107 were used to perform the analysis. A modified version of flask method indicated in the OECD 107 was used in order to assess the octanol/water partition coefficient. In particular, the test material concentrations in water and octanol were analyzed by liquid chromatography. Octanol/water partition coefficient of the test material is comprised between -1.97 and -1.17 at ambient temperature.
Reference
Weight of sample (g) | Volume of Water (mL) | Volume of octanol (mL) | Weight in water (g) | Weight in octanol (g) | Conc in water (g/mL) | Conc in octanol (g/mL) | Coef | Logp |
0.5204 | 25 | 75 | 0.2923 | 0.0095 | 1.17E-02 | 1.27E-04 | 1.08E-02 | -1.97 |
0.5103 | 50 | 50 | 0.3437 | 0.0045 | 6.87E-03 | 9.00E-05 | 1.31E-02 | -1.88 |
0.5514 | 75 | 25 | 0.3972 | 0.0017 | 5.30E-03 | 6.80E-05 | 1.28E-02 | -1.89 |
1.0075 | 25 | 75 | 0.5916 | 0.0255 | 2.37E-02 | 3.40E-04 | 1.44E-02 | -1.84 |
1.027 | 50 | 50 | 0.7191 | 0.0347 | 1.44E-02 | 6.94E-04 | 4.83E-02 | -1.32 |
0.9983 | 75 | 25 | 0.7742 | 0.0173 | 1.03E-02 | 6.92E-04 | 6.70E-02 | -1.17 |
Description of key information
Octanol/water partition coefficient of the substance is comprised between -1.97 and -1.17 at ambient temperature.
The mean value of the octanol/water partition coefficient at ambient temperature is -1.68.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.68
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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