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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from a secondary source.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Radiolabelling:
- not specified
- Analytical monitoring:
- yes
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- - Other: Rapid hydrolysis of this material produces ethanol and trisilanols.
- pH:
- 7
- Temp.:
- 10 °C
- DT50:
- 56 h
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- pH:
- 7
- Temp.:
- 24.7 °C
- DT50:
- 8.4 h
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- pH:
- 7
- Temp.:
- 37 °C
- DT50:
- 3.9 h
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Half life at different pH were determined to be 56h, 8.4h, and 3.9 h respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
- Executive summary:
The rate of hydrolysis study was carried out at different pH 4, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically using HPLC and ICP-AES. Rapid hydrolysis of this material produces ethanol and trisilanols. Half life at different pH were determined to be 56h, 8.4h, and 3.9 h respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from a secondary source.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- yes
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- - Other: Rapid hydrolysis of this material produces methanol and trisilanols.
- pH:
- 7
- Temp.:
- 10 °C
- DT50:
- 0.1 h
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- pH:
- 7
- Temp.:
- 24.7 °C
- DT50:
- 0.025 h
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- pH:
- 7
- Temp.:
- 37 °C
- DT50:
- 0.009 h
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Rate of hydrolysis study was carried out at different pH 4, 5, 7 and 9. Half life at different pH were determined to be 0.10, 0.025, 0.0090 hr respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
- Executive summary:
Rate of hydrolysis study was carried out at different pH 4, 5, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically APCI-MS. Rapid hydrolysis of this material produces methanol and trisilanols. Half life at different pH were determined to be 0.10, 0.025, 0.0090 hr respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
- Endpoint:
- hydrolysis
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Estimated data generated using the EPI Suite model developed by the USEPA.
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- HYDROWIN Program (v2.00) from EPI Suite estimation database
- GLP compliance:
- no
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Estimation method (if used):
- HYDROWIN v2.00
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- pH:
- 4
- DT50:
- 1.1 - 24 min
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- pH:
- 5
- DT50:
- 13 - 155 min
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 28 - 504 min
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- pH:
- 9
- DT50:
- 0.04 - 340 min
- Type:
- not specified
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water. Half-life using the HYDROWIN Program (v2.00) of EPI suite was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
- Executive summary:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water. Half-life using the HYDROWIN Program (v2.00) of EPI suite was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Referenceopen allclose all
Description of key information
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 56 h
- at the temperature of:
- 24.7 °C
Additional information
Predicted data of target chemical and supporting weight of evidence studies for it's structurally similar read across chemicals has been reviewed to determine the effect of the test chemical in water. The studies are as mentioned below:
First study includes estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Second study includes rate of hydrolysis study was carried out at different pH 4, 5, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically APCI-MS. Rapid hydrolysis of this material produces methanol and trisilanols. Half life at different pH were determined to be 0.10, 0.025, 0.0090 hr respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
Third study includes the rate of hydrolysis study was carried out at different pH 4, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically using HPLC and ICP-AES. Rapid hydrolysis of this material produces ethanol and trisilanols. Half life at different pH were determined to be 56h, 8.4h, and 3.9 h respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Based on above information test chemical was considered as hydrolyzable i.e unstable in water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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