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Diss Factsheets
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EC number: 908-820-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study according to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of (E)-1-chlorobut-2-ene and 3-chlorobut-1-ene
- EC Number:
- 908-820-9
- Molecular formula:
- not applicable
- IUPAC Name:
- Reaction mass of (E)-1-chlorobut-2-ene and 3-chlorobut-1-ene
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
- Water solubility (under test conditions): not applicable, hydrolysis
- Stability in water: hydrolysis
- Results of test for ready biodegradability: not ready biodegradable
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- For stability control a series of the concentrations tested, was made up in the same way as the concentrations for biological part, but in separate vessels without test organisms ans NaHCO3
Sampling time : 0 and 48h
Test solutions
- Vehicle:
- no
- Details on test solutions:
- For stock solution, 1.1 ml of the test item were mixed with 1000 mL synthetic fresh water without NaHCO3 for about 1h in an open vessel under a laboratory hood and than the vessel was closed. The resulting solution served as stock solution with a measured analytical value of 420 mg TOC/L resp. 793 mg test item/L
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Strauss clone 5
- Source: inhosue breeding (origined from Bayer AG, 1991)
- Age at study initiation (mean and range, SD): 24h
- Method of breeding: females maintained in M4 medium in 1L beakers, at two to three day intervals, teh excuviae are sphoned off and the water is changed, offspring is removed from the breeding vessels; in a four week interval, offspring is isolated from the vessel and serve as a basis for further breeding
- Feeding during test
no
ACCLIMATION
- Acclimation period: 24h in synthetic water
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no
Test conditions
- Hardness:
- 14°dH
- Test temperature:
- 20 +- 1°C
- pH:
- begin of the test: control: 8.1, concentration dependent decrease of a pH with 8.1 (2.77 mg/L) down to 3.9 at 79.3 mg/L
end of the test: control: 7.8, concentration dependent decrease with 7.4 (2.77 mg/L) down to 4.0 (79.3 mg/L), no major difference for the two endpoints measured - Dissolved oxygen:
- Begin of the test: 7.7-8.1
End of the test: 7.8-8.7 - Salinity:
- no
- Nominal and measured concentrations:
- measured test concentrationss (DOC) after 48h ranges from 87-101% compared to the initial DOC values, therefore, the bological values were calculated with the nominal concentrations
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: closed (gas tight septum)
- Material, size, headspace, fill volume: 22 mL head-space test tubes volume inside the test vessel was increased to 20 mL resulting in a reduced gas phase
- Aeration: no
- No. of organisms per vessel: 5 organisms
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: not reported
- Ca/mg ratio: 4:1
- Na/K ratio: 10:1
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: dark
- Light intensity: not applicable
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations:
- Justification for using less concentrations than requested by guideline:
- Range finding study: no details reported in the final report - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 61 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not given
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 42 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not given
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- 28 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no
- The high toxicity at the highest concentration may be due to the low pH level (3.9-4.0) - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Mortality: yes
- EC50/LC50: 1 mg/L < 50% effect, 2 mg/L >50% effect
- Other: Reference item was tested quartely - Reported statistics and error estimates:
- Due to the strong dose-response relationship, the EC50 values after 24h and 48h were calculated graphically.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under conditions tested , the LC50 value after 48h of test item and its hydrolysis products is 42 mg/L. The toxicity observed can be regarded as pH effects (pH < 6.2 at concentrations >= 47.6)
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