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EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Remarks:
- Honey bee (oral and contact)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 213 (Honeybees, Acute Oral Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 214 (Honeybees, Acute Contact Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Application method:
- other: Oral and Contact
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
- Remarks:
- 50% w/v sucrose solution with 2.5% DMSO for oral toxicity and Tap water with ca. 0.5% Adhäsit® and 10% DMSO for contact toxicity
Test organisms
- Test organisms (species):
- Apis mellifera
- Animal group:
- Hymenoptera (honeybees)
Study design
- Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 25°C
- Humidity:
- 51 - 84%
- Photoperiod and lighting:
- Darkness (except during observation)
- Nominal and measured concentrations:
- Contact test: 100, 50, 25, 12.5 and 6.25 μg a.i./bee
Oral test: 110.0, 55.0, 27.3, 13.4 and 7.0 μg a.i./bee - Reference substance (positive control):
- yes
- Remarks:
- Perfekthion (dimethoate a.s.)
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Remarks:
- Oral
- Effect conc.:
- > 110 other: μg a.i./bee
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Remarks:
- Contact
- Effect conc.:
- > 100 other: μg a.i./bee
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- other: NOED (Oral)
- Effect conc.:
- 110 other: μg a.i./bee
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- other: NOED (contact)
- Effect conc.:
- 100 other: μg a.i./bee
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Results with reference substance (positive control):
- The 24-hour oral and contact LD50 values for the reference item were 0.12 and 0.13 μg dimethoate/bee, respectively.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Honey bee 48 h contact LD50: >100 μg a.i./bee
Honey bee 48 h Contact NOED: 100 μg a.i./bee
Honey bee 48 h oral LD50: >110 μg a.i./bee
Honey bee 48 h Oral NOED: 110 μg a.i./bee - Executive summary:
The aim of this study was to determine the acute contact and oral toxicity of the test item to the honey bee (Apis mellifera L.) in a laboratory study. A contact test with 100, 50, 25, 12.5 and 6.25 μg a.i./bee and an oral test with 110.0, 55.0, 27.3, 13.4 and 7.0 μg a.i./bee were conducted under OECD Guidelines 213 and 214 (1998).
In the contact test dose levels of 100, 50, 25, 12.5 and 6.25 μg a.i./bee led to no mortality at test end (48 hours after application). In the water control group (tap water containing 0.5% Adhäsit) as well as in the solvent control group (tap water with 0.5% Adhäsit and 10% DMSO) 3.3% mortality occurred.
In the oral test the target dose levels of 100, 50, 25, 12.5 and 6.25 μg a.i./bee would have been achieved if each bee ingested exactly 20 mg of the treated feeding solution. Actual oral doses of 110.0, 55.0, 27.3, 13.4 and 7.0 μg a.i./bee led to mortalities of 6.7, 0.0, 3.3, 3.3 and 3.3% at test end (48 hours after application), respectively. In the water control group (50% w/v sucrose solution) 3.3% mortality was observed. No mortality occurred in the solvent control group (50% w/v sucrose solution containing 2.5% DMSO).
No test item related behavioural abnormalities occurred at any time in both toxicity tests.
The effects of the test item on the honey bee (Apis mellifera L.) were assessed in an acute contact and oral toxicity test, conducted in the laboratory. The 48 h contact LD50 – based on analytical a.i.-content – was >100 μg a.i./bee and the contact NOED was 100 μg a.i./bee. The 48 h oral LD50 – based on analytical a.i.-content – was >110 μg a.i./bee and the oral NOED was 110 μg a.i./bee.
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