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EC number: 617-251-2 | CAS number: 816431-72-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Apr 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- no
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Remarks:
- HPLC-UV
- Details on sampling:
- - Sampling method: Aliquots of the dilutions were taken and tempered at 50°C for 2.5 hours.
- Buffers:
- - pH: 4, 7 and 9
- Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks: volumetric flasks
- other equipment used: ultrasonic bath
TEST MEDIUM
- Volume used: 25 mL
- Kind and purity of water: distilled water - Duration:
- 2.5 h
- pH:
- 4
- Temp.:
- 50 °C
- Remarks:
- Preliminary test
- Duration:
- 2.5 h
- pH:
- 7
- Temp.:
- 50 °C
- Remarks:
- Preliminary test
- Duration:
- 2.5 h
- pH:
- 9
- Temp.:
- 50 °C
- Remarks:
- Preliminary test
- Number of replicates:
- 1 replicate for each pH value and temperature.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- The experiments using buffers at pH 4, pH 7 and pH 9 as well as the experiment with distilled water showed that the test substance is not stable in contact with water.
- Test performance:
- The degradation was so fast, that the test substance could not be detected by HPLC and LC-MS.
- Transformation products:
- yes
- No.:
- #1
- Details on hydrolysis and appearance of transformation product(s):
- - Formation and decline of each transformation product during test: A by-product could be detected in all experiments (approx. 7 % at pH 9) through the area percentage ratio between the peaks.
- Pathways for transformation: HPLC analyses indicated that the hydrolysis yields the corresponding carbonic acid as the main component.
- Remarks on result:
- not determinable
- Remarks:
- The degradation was so fast, that the test substance could not be detected by HPLC and LC-MS. The period of time between starting the hydrolysis (contact with water) and injection into the HPLC-system was max. 30 min. Therefore the resulting half-life time was estimated to be below 10 min.
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
- Anomalies or problems encountered: The degradation was so fast, that the test substance could not be detected by HPLC and LC-MS. The period of time between starting the hydrolysis (contact with water) and injection into the HPLC-system was max. 30 min. Therefore the resulting half-life time was estimated to be below 10 min.
MAJOR TRANSFORMATION PRODUCTS
A by-product could be detected in all experiments (approx. 7 % at pH 9). HPLC analyses indicated that the hydrolysis yields the corresponding carbonic acid as the main component.
PATHWAYS OF HYDROLYSIS
- Description of pathways: HPLC analyses indicated that the hydrolysis yields the corresponding carbonic acid as the main component.
- Figures of chemical structures attached: Yes
SUPPLEMENTARY EXPERIMENT:
In order to verify that the test substance was present before conducting the hydrolysis experiments, the substance was converted with cyclo-propylamine by derivatization. The derivatization experiment approved that the derivatized substance was present, yielding 93 % of the theoretical amount, considering the purity of the test substance (92.6 %). - Validity criteria fulfilled:
- yes
- Remarks:
- See more details in the table in the section "Any other information on results incl. tables"
- Conclusions:
- The test substance is not stable in contact with water.
- Executive summary:
Hydrolysis of the test substance at 53.9 mg (pH 4), 56.9 mg (pH 7) and 58.3 mg (pH 9) dissolved in buffer of volume of 25 mL was studied for 2.5 h. The experimental protocol is comparable to preliminary test of the EU method C.7 (Degradation: Hydrolysis as a function of pH). Aliquots of the dilutions were taken and tempered at 50°C for 2.5 hours. The solutions were analysed by HPLC before and after the tempering period. Identification of the transformation products was done by HPLC and LC-MS.
The experiments using buffers at pH 4, pH 7 and pH 9 showed that the test substance is not stable in contact with water. The degradation was so fast, that the test substance could not be detected by HPLC and LC-MS. The period of time between starting the hydrolysis (contact with water) and injection into the HPLC-system was max. 30 min. Therefore the resulting half-life time was estimated to be below 10 min. A by-product could be detected in all experiments (approx. 7 % at pH 9). HPLC analyses indicated that the hydrolysis yields the corresponding carbonic acid as the main component and this was confirmed using LC/MS analyses.
In order to verify that the test substance was present before conducting the hydrolysis experiments, the substance was converted with cyclo-propylamine by derivatization. The derivatization experiment approved that the derivatized substance was present, yielding 93 % of the theoretical amount.
Reference
Validity criteria
Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
The analytical method must be sufficiently precise and sensitive to detect a reduction of 10 % of the initial concentration. | Analysis via HPLC is sensitive enough to detect a reduction of 10% of the initial concentration. However the substance was unstable and undetected. | Yes |
The method must be specific to allow determination of the test substance at the test solution concentrations and may well consist of some combination of suitable analytical techniques. | The derivatized product of the test substance could be measured by the analytical method | Yes |
The test substance should be dissolved in the selected buffer and the concentration should not exceed 0.01 M or half the saturation concentration, whichever is the lower. | 57 mg (pH 7) were dissolved in 25 mL (i.e. 4.4E-3 mol/L) | Yes |
Description of key information
Hydrolysis of the test substance at 53.9 mg (pH 4), 56.9 mg (pH 7) and 58.3 mg (pH 9) dissolved in buffer of volume of 25 mL was studied for 2.5 h. The experimental protocol is comparable to preliminary test of the EU method C.7 (Degradation: Hydrolysis as a function of pH). Aliquots of the dilutions were taken and tempered at 50°C for 2.5 hours. The solutions were analysed by HPLC before and after the tempering period. Identification of the transformation products was done by HPLC and LC-MS.
The experiments using buffers at pH 4, pH 7 and pH 9 showed that the test substance is not stable in contact with water. The degradation was so fast, that the test substance could not be detected by HPLC and LC-MS. The period of time between starting the hydrolysis (contact with water) and injection into the HPLC-system was max. 30 min. Therefore the resulting half-life time was estimated to be below 10 min. A by-product could be detected in all experiments (approx. 7 % at pH 9). HPLC analyses indicated that the hydrolysis yields the corresponding carbonic acid as the main component and this was confirmed using LC/MS analyses.
In order to verify that the test substance was present before conducting the hydrolysis experiments, the substance was converted with cyclo-propylamine by derivatization. The derivatization experiment approved that the derivatized substance was present, yielding 93 % of the theoretical amount.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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