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EC number: 205-440-9 | CAS number: 140-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Sodium ethyl xanthate: Acute Oral, Eye and Dermal Toxicity Report
- Author:
- Hazleton Laboratories
- Year:
- 1 951
- Bibliographic source:
- Acute Oral, Eye and Dermal Toxicity Report”, Virginia, USA, 1951.
- Reference Type:
- review article or handbook
- Title:
- Oral toxicity of xanthates
- Author:
- Kirk-Othmer Encyclopaedia of Chemical Technology
- Year:
- 1 984
- Bibliographic source:
- Vol 24, 2nd ed, pp 645-661, John Wiley & Sons, 1984.
- Reference Type:
- review article or handbook
- Title:
- Priority existing chemical Report No. 5
- Author:
- Dep. of Health and Ageing, Australian Government
- Year:
- 1 995
- Bibliographic source:
- National Industrial Chemicals Notification and Assessment Scheme
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The study was carried out in 1951 and complies generally with current test protocols such as the Organisation for Economic Cooperation and Development (OECD) guidelines for testing of chemicals No. 401. This study predates the requirements for good laboratory practice, however the study was considered adequate for this assessment. A 10% aqueous solution of sodium ethyl xanthate was administered orally by gavage. The pH of the solution was approximately 10.5 to 11. The animals were observed for signs of gross toxicological effects for seven days.
- GLP compliance:
- no
- Test type:
- other: LD50
- Limit test:
- no
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
- Test material form:
- solid: bulk
- Details on test material:
- SEX /sodium O-ethyl dithiocarbonate is produced by the reaction of an ethyl alcohol with sodium hydroxide to form alcoholate and subsequently adding carbon disulfide to form SEX/ sodium O-ethyl dithiocarbonate.
SEX /sodium O-ethyl dithiocarbonate contains Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) which are an integral part of the substance.
Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) are both reagents used in the manufacture of SEX /sodium O-ethyl dithiocarbonate. Therefore, Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) need to be considered in the assessment of SEX /sodium O-ethyl dithiocarbonate.
CAS name: ethyl alcohol
EC / List name: Ethanol
IUPAC name: ethanol
EC / List no.: 200-578-6
CAS no.: 64-17-5
CAS name: sodium hydroxide
EC / List name: Sodium hydroxide
IUPAC name: sodium hydroxide
EC / List no.: 215-185-5
CAS no.: 1310-73-2
1
Test animals
- Species:
- mouse
- Strain:
- other: albino mice
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 500,600,750,900,1000,1500,2000,5000 mg
- No. of animals per sex per dose:
- 93 male
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 730 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The majority of deaths occurred on the first day and the animals that survived appeared normal within two days. The study does not indicate how many animals developed the symptoms, at what doses and the day of development of the symptoms.
- Clinical signs:
- other: Depression followed by hyperexcitability, tremors, paralysis, exophthalmia and clonic followed by tonic convulsions. Pinkness of feet and nose, preening and salivation.
- Gross pathology:
- Consolidated lungs, pale granular livers, unusually small spleens and atonic
intestines. Surviving animals showed no abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- other: sligthly toxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value of 730 mg/kg was determined in a reliable study. This show that 10% aqueous solution of sodium ethyl xanthate is of a Slightly order of acute oral toxicity .
Based on the data provided in this review, SEX shall be classified for acute oral toxicity. - Executive summary:
The results of this study indicate that a 10% aqueous solution of sodium ethyl xanthate has an oral LD50 of 730 mg/kg in male mice. The target organs for oral toxicity of sodium ethyl xanthate were the central nervous system, liver and spleen.
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