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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Assessment of the toxicokinetik behaviour of the test substance (CAS 123 -54 -6):
The test substance (molecular weight of 100.1 g/mol) is a yellow transparent liquid (BRRC, 1985) with a log Pow of 0.05, a water solubility of 53 g/L, and a vapor pressure of 1136 Pa (calculated from Epiwin).
Absorption
Mortality and clinical signs were observed after oral and dermal administration of the test substance (see chapter "Acute toxicity" and "Repeated dose toxicity"), which indicates a systemic distribution of the test substance.
In an inhalation study conducted in male Fischer 344 rats it could be shown that 14C-labeled 2,4-pentanedione was readily absorbed by the inhalation route. Nose-only exposure to 400 ppm 14C-labeled 2,4-pentanedione resulted in a rapid increase in plasma radioactivity during the first 3 hours of exposure, with a tendency to plateau toward the end of the 6 hour exposure period (BRRC, 1995).
Metabolism
Plasma unmetabolized 14C-labeled 2,4-pentanedione was present throughout the whole of the exposure phase in the inhalation study, but was significantly less than total 14C (BRRC, 1995). Immediately postexposure, radioacivity was present in all tissues examined, but on a concentration basis (μg equivalents/g) there was no preferential accumulation of 14C in any tissue or organ. On a total organ basis, highest contents were in liver and kidneys. Postexposure, plasma unmetabolized 14C-labeled 2,4 -pentanedione declined rapidly to undetectable concentrations by 12 hours (BRRC, 1995). After intravenous administration, there was relatively rapid clearanee of 14C from plasma, with a mean residence time of 10.3 to 12.8 hr. The apparent volume of distribution ranged from 0.78 to 2.49 L/kg, suggesting that 14C-2,4 -Pentanedione was distributed beyond the lotal body water (about 0.58 L/kg), and likely sequestered in certain lipid components.
Excretion
Elimination of 14C from plasma followed a biphasic pattern with a terminal half-life of 30.72 hours. Excretion over 48 hour; of 14C was approximately equivalent between urine (37.6 %, mainly not identified metabolites) and expired14CO2(36.3 %), which the most part of the radioactivity was eliminated in the first 12 hours. Expired volatiles, feces, tissues and carcass accounted for 2.29, 2.78, 1.66 and 17.15 % of the total administered radioactivity dose 48 hours postdosing, respectively (BRRC, 1995). Excretion of radiolabel after intravenous administration was predominantly in urine and as 14CO2 with most of the radiolabel being eliminated in the first 24 hr. Up to, and including the 148,5 mg/kg intravenous dose, total 48 hr elimination as 14CO2 was relatively constant (36.84-41.31%) but urinary 14C excretion showed a progressive and dose-related increase. At 430 mg/kg there was a route reversal in the proportion of radiolabel exereted, with urinary radiolabel being about one-half that for 14CO2. This change in the excretory profile at the highest intravenous dose could be the result of saturation of one of the metabolic pathways for 2,4 -pentanedione and is consistent with non-linear kinetic behaviour at this dose. For all doses, excretion as volatiles in expired air was low.
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