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EC number: 247-728-7 | CAS number: 26479-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Potassium allophonate was negative in an in vitro bacterial reverse mutation assay (Ames assay) performed according to GLP and OECD Testing Guideline 471 (Covance, 2012g). In this test, two bacterial species, Salmonella typhimurium and Escherichia coli, were tested at potassium allophonate concentrations up to 5000 µg/plate both in the presence and absence of a rat liver S9 microsomal fraction metabolic activation system. In an in vitro micronucleus assay performed according to GLP and OECD Testing Guideline 487, potassium allophonate was studied for its potential to induce micronuclei formation in human lymphocytes in the absence and presence of a rat liver S9 microsomal fraction metabolic activation system. Potassium allophonate did not induce biologically relevant micronuclei in cultured human peripheral blood lymphocytes when tested up to 10 mM in both the absence and presence of S9 and, therefore, the results of this test were determined to be negative. An in vitro mammalian cell gene mutation assay (MGMA), performed under GLP and according to OECD Testing Guideline 476, is available testing potassium allophonate. In this study, mouse lymphoma L5178Y cells were tested at concentrations of potassium allophonate up to 10 mM both in the absence and presence of a rat liver S9 microsomal fraction metabolic activation system. In this study, potassium allophonate did not induce mutation at the thymidine kinase locus when tested with and without metabolic activation; therefore, the results of this study were determined to be negative.
References:
Covance. 2012g. Reverse mutation in four histidine-requiring strains of Salmonella typhimurium and one tryptophan-requiring strain of Escherichia coli. Testing laboratory: Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire HG3 1PY ENGLAND. Report no.: 8249504. Owner company: Kerr Fire Fighting Chemicals, Ashcroft Road, Knowsley Industrial Park, Kirby, Liverpool L33 7TS. Study number: 8249504. Report date: 2012-04-23.
Covance. 2012h. Mutation at the thymidine kinase (tk) locus of mouse lymphoma L5178Y cells (MLA) using the Microtitre fluctuation technique. Testing laboratory: Covance Laboratories Ltd Otley Road, Harrogate, North Yorkshire HG3 1PY ENGLAND. Report no.: 8251472. Owner company: Kerr Fire Fighting Chemicals, Ashcroft Road, Knowsley Industrial Park, Kirby, Liverpool L33 7TS. Report date: 2012-10-15.
Covance. 2012i. Induction of micronuclei in cultured human peripheral blood lymphocytes. Testing laboratory: Covance Laboratories Ltd Otley Road, Harrogate, North Yorkshire HG3 1PY ENGLAND. Report no.: 8251471. Owner company: Kerr Fire Fighting Chemicals, Ashcroft Road, Knowsley Industrial Park, Kirby, Liverpool L33 7TS. Report date: 2012-04-24.
Short description of key information:
Potassium allophonate was negative for mutagenicity in an in vitro micronucleus test according to Good laboratory Practices (GLP) and Organisation for Economic Co-operation and Development (OECD) Testing Guideline 487, an in vitro bacterial reverse mutation assay according GLP and OECD Testing Guideline 471 and an in vitro L5178Y TK+/- mouse lymphoma forward mutation assay according to GLP and OECD Testing Guideline 476.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Potassium allophonate was negative for mutagenicity in an in vitro micronucleus test according to GLP/OECD Testing Guideline 487, an in vitro bacterial reverse mutation assay according to GLP/OECD Testing Guideline 471 and an in vitro L5178Y TK+/- Mouse lymphoma forward mutation assay according to GLP/OECD Testing Guideline 476.Given the absence of positive results in mutagenicity assays, potassium allophonate is not considered genotoxic and therefore does not warrant classification for genetic toxicity.
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