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EC number: 236-152-1 | CAS number: 13194-48-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethoprophos
- EC Number:
- 236-152-1
- EC Name:
- Ethoprophos
- Cas Number:
- 13194-48-4
- Molecular formula:
- C8H19O2PS2
- IUPAC Name:
- ethyl bis(propylsulfanyl)phosphinate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Age at study initiation: 2.4 - 2.5 kg
- Weight at study initiation: not specified
- Housing: individually, in elevated metal cages
- Diet (ad libitum): Furina Rabbit Pellets
- Water (ad libitum): yes
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- not applicable, no washing
- Observation period (in vivo):
- 1 h
- Number of animals or in vitro replicates:
- 3 animals per sex
- Details on study design:
Prior to application, the left eye of each rabbit was examined with 2.0% sodium fluorescein solution to detect any corneal lesions not otherwise visible, and only those animals with eyes free of irritation and corneal damage were used in this study.
A single application of 0.1 mL of the undiluted test material was made into the conjunctival sac of the left eye of each animal. The treated eye was held closed for 30 seconds following application.
The animals were observed for signs of eye irritation and systemic toxicity immediately following instillation and for signs of systemic toxicity during the period preceding death. Necropsies were performed on the animals following death.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Remarks on result:
- not determinable
- Remarks:
- due to acute toxicity (mortality) within 15 min
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 3
- Remarks on result:
- not determinable
- Remarks:
- due to acute toxicity (mortality) within 15 min
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 4
- Remarks on result:
- not determinable
- Remarks:
- due to acute toxicity (mortality) within 15 min
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 2
- Remarks on result:
- not determinable
- Remarks:
- due to acute toxicity (mortality) within 15 min
- Irritant / corrosive response data:
- Immediately following application of the test item, moderate erythema and vascularization of the sclera and nictitating membrane were noted in all of the treated eyes.
- Other effects:
- MORTALITY
Within an additional 15 minutes toxic signs were noted in each animal and all animals were dead prior to the one-hour observation.
CLINICAL SIGNS
The following toxic signs were noted: preening, excessive masticatory movements, salivation, blinking, miosis, incoordination of limbs, rapid labored respiration, tremors, clonic and tonic convulsions, and death.
GROSS PATHOLOGICAL EXAMINATION
Necropsies revealed congestion of the lungs, liver, and kidneys and gaseous distention of the gastrointestinal tract.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- A single application of 0.1 mL of the undiluted test substance to the eyes of albino rabbits produced, in all three animals, death within one hour following instillation. Due to the high toxicity of the test item to the rabbit, eye irritating properties were not further investigated.
- Executive summary:
In an experimental study from 1965, similar to OECD 405, 0.1 mL of the undiluted test substance was instilled to the left eye of 3 male and female rabbits. The remaining untreated eye served as a control. The animals were observed for signs of eye irritation and systemic toxicity immediately following instillation. Immediately following application of the test item, moderate erythema and vascularization of the sclera and nictitating membrane were noted in all of the treated eyes.
Within an additional 15 minutes toxic signs were noted in each animal and all animals were dead prior to the one-hour observation. The following toxic signs were noted: preening, excessive masticatory movements, salivation, blinking, miosis, incoordination of limbs, rapid labored respiration, tremors, clonic and tonic convulsions, and death. Necropsy was performed and revealed congestion of the lungs, liver, and kidneys and gaseous distention of the gastrointestinal tract.
Under the test condition, the test items eye irritation potential could not be evaluated as all animals died due to the high toxicity of the test item in the rabbit. Therefore, the eye irritating property of the test item was not further investigated.
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