Registration Dossier
Registration Dossier
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EC number: 433-460-1 | CAS number: 210880-92-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Qualifier:
- according to guideline
- Guideline:
- other: EPA OPPTS 830.7840
- GLP compliance:
- no
- Medium:
- acetone
- Solubility:
- 15.2 g/L
- Temp.:
- 25 °C
- Medium:
- methanol
- Solubility:
- 6.26 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Solubility:
- 2.03 g/L
- Temp.:
- 25 °C
- Medium:
- other: dichloromethane
- Solubility:
- 1.32 g/L
- Temp.:
- 25 °C
- Medium:
- n-octanol
- Solubility:
- 0.938 g/L
- Temp.:
- 25 °C
- Medium:
- other: xylene
- Solubility:
- 0.013 g/L
- Temp.:
- 25 °C
- Medium:
- other: n-heptane
- Solubility:
- < 0.001 g/L
- Temp.:
- 25 °C
- Test substance stable:
- yes
Reference
Fortified samples were prepared in each solvent to demonstrate the validity of the method and the stability of the test substance in solution. All average recoveries were in the range of 85 to 120%. The relative standard deviation for the replicate samples at each time point was less than 10% for each solvent. There were no trends in the solubility data for any of the solvents indicating that equilibration had not been reached.
Description of key information
Average Solubility (g/L) at 25 °C:
Acetone: 15.2
Methanol: 6.26
Ethyl acetate: 2.03
Dichloromethane: 1.32
n-Octanol: 0.938
Xylene: 0.0128
Heptane: <0.00104
Key value for chemical safety assessment
Additional information
The solubility of the substance in organic solvents was determined according to the guideline applicable for water solubility, i.e. OECD 105
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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