Registration Dossier
Registration Dossier
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EC number: 429-100-6 | CAS number: 23911-56-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-09-04 to 1998-09-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 187 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 7.9
- Key result
- Water solubility:
- 191 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 48 h
- Temp.:
- 20 °C
- pH:
- 7.9
- Key result
- Water solubility:
- 190 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 7.8
- Conclusions:
- The water solubility of the test item was determined to be 189 mg/L at 20°C.
- Executive summary:
A study of water solubility of the test item was conducted according to EG-guideline 92/69 method A.6 and GLP. Based on the result from the preliminary study the flask method was applied. Three flasks with test item were prepared and incubated at 30 °C for 24, 48 and 72 h, followed by incubation at 20 °C for 24 h. The pH-values were measured with a pH-meter. The concentrations were analyzed by high performance liquid chromatography. On the basis of the method the water solubility of the test item was determined to 189 mg/L at 20 °C.
Reference
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 189 mg/L
- at the temperature of:
- 20 °C
Additional information
A study of water solubility of the test item was conducted according to EG-guideline 92/69 method A.6 and GLP. Based on the result from the preliminary study the flask method was applied. Three flasks with test item were prepared and incubated at 30 °C for 24, 48 and 72 h, followed by incubation at 20 °C for 24 h. The pH-values were measured with a pH-meter. The concentrations were analyzed by high performance liquid chromatography. On the basis of the method the water solubility of the test item was determined to 189 mg/L at 20 °C.
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