Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-520-1 | CAS number: 131807-57-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 November 1993 - 10 February 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.8 (Toxicity for Earthworms: Artificial Soil Test)
- Version / remarks:
- 1979
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Version / remarks:
- 1984
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Purity: 97.4%
Batch: DPX-JE874-221 - Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- acetone
- Details on preparation and application of test substrate:
- Weighed amounts of DPX-JE874-221 were dissolved in acetone (60 ml range finding test and 120 ml definitive test) and added to the premixed soil on the day of the test (2 kg per concentration range finding test and 3 kg per concentration definitive test). This was then blended in a laboratory mixer for ca 5 min. The acetone was allowed to evaporate (ca 4 h) and the soil returned to the mixer. The soil was blended for a further 5-10 min, during which deionised water (316 ml range finding test and 464 ml definitive test) was slowly added to give a theoretical moisture content of 35%. Acetone alone was added to the solvent control soil and no acetone was added to the non-solvent control.
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- Earthworms (Eisenia foetida andrei) at least 2 months old (with clitellum) and weighing between 300 and 600 mg were used for this study, and were obtained from Ecology Earthworms, Suffolk
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Remarks:
- Industrial sand: 70%; Kaolinite clay: 20%; Sphagnum moss peat: 10%. The pH of the soil was adjusted to 6.0 ± 0.5 by the addition of CaC03; the amount added during the tests was equivalent to 0.5% of the total dry weight.
- Total exposure duration:
- 14 d
- Test temperature:
- 19-23°С
- pH:
- 6.2 - 6.5
- Moisture:
- Day 0: 29-33%
Day 14: 24-31% - Details on test conditions:
- Moulded glass beakers of capacity ca 1 litre, and covered with perforated plastic film to retard evaporation, were used for this test. Test and control vessels each contained ca 750 g (wet weight) soil. Earthworms were added to the test and control soils approximately 5 h after the test
material was added to the premixed soil.
Rangefinding Study: A range finding test was conducted over a 14 day period at nominal concentrations of 0, 1, 10, 100, and 100 ppm. A non-solvent control was also prepared.
One vessel was prepared at each concentration, and 10 earthworms added per vessel.
Definitive Study: Four vessels were prepared at each concentration, and 10 earthworms added per vessel. The earthworms in the definitive test were observed daily throughout the test. Any abnormalities in behaviour (absence of burrowing, lethargy or colour change) and any deaths were noted. Mortalities were recorded after 7 and 14 days. - Nominal and measured concentrations:
- Nominal: 0, 62.5, 125, 250, 500, and 1000 ppm
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 470 other: ppm
- Basis for effect:
- mortality
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- 815 other: ppm
- Nominal / measured:
- nominal
- Basis for effect:
- mortality
- Details on results:
- Rangefinder: At the end of the 14 day period, 100% mortalities had occurred at 1000 ppm nominal, 10% mortalities at 100 ppm. and 10% at 0 ppm. (non-solvent). No mortalities occurred at 10 ppm., 1 ppm, and 0 ppm (solvent). Due to 100% mortality at 1000 ppm. nominal concentration DPX-JE874-221, a definitive test was conducted with a top nominal concentration of 1000 ppm.
In both the range finding and definitive tests, any worms not found in the soil were assumed to have decomposed and therefore counted as mortalities.
Definitive study: After 14 days, a 47% decrease in body weight had occurred at 1000 ppm, 29% at 500 ppm, 28% at 250 ppm, 22% at 125 ppm and 17% at 62.5 ppm. The worms in the solvent and non-solvent control vessels decreased in body weight by 6.6% and
8.9% respectively.
The intercept and dose response curve and hence LC50 were estimated by applying the standard technique of maximum likelihood estimation to the probit model.
7-day LC50 = 815 ppm (95% confidence limits of 656 to >1000 ppm)
14-day LC50 = 470 ppm (95% confidence limits of 389 to 581 ppm) - Validity criteria fulfilled:
- yes
- Conclusions:
- 7-day LC50 = 815 ppm (95% confidence limits of 656 to >1000 ppm)
14-day LC50 = 470 ppm (95% confidence limits of 389 to 581 ppm) - Executive summary:
The acute toxicity (LC50) of DPX-JE874-221 to earthworms (Eisenia foetida andrei) was
determined over a 14 day period. The test was conducted according to OECD guideline 207 and EC Guideline, Annex V, Part C, Toxicity for Earthworms, Artificial Soil Test. Nominal concentration of 0, 62.5, 125, 250, 500, and 1000 ppm were tested. A non-solvent control was also prepared.
Forty earthworms were exposed at each concentration in the definitive test. The earthworms in the definitive test were observed daily throughout the test. Any abnormalities in behaviour (absence of burrowing, lethargy or colour change) and any deaths were noted. Mortalities were recorded after 7 and 14 days. Absence of burrowing was observed at 1000, 500, 250 and 125 ppm. No abnormalities in appearance were observed at any concentration. The 7-day LC50 was 815 ppm (95% confidence limits of 656 to >1000 ppm) and the 14-day LC50 was 470 ppm (95% confidence limits of 389 to 581 ppm).
Reference
Definitive Test: All worms burrowed into soil within 5 min of addition to vessels. Worms were observed on the soil surface in test vessels at 1000, 500 and 250 ppm over the 7 day period. By Day 14, Worms were observed on the soil surface in test vessels at 1000, 500 and 250 ppm and one worm at 125 ppm over the 14 day period.
| % Mortality | % Mortality |
| Day 7 | Day 14 |
0 (non-solvent) | 0% | 0% |
0 (solvent) | 0% | 0% |
62.5 | 0% | 0% |
125 | 0% | 5% |
250 | 7.5% | 155 |
500 | 35% | 57.5% |
1000 | 55% | 77.5% |
In both the range finding and definitive tests, any worms not found in the soil were assumed to have decomposed and therefore counted as mortalities.
Description of key information
14-day LC50 (earthworms, Eisenia foetida andrei) = 470 ppm, OECD 207 and EC Method C.8, Reliability = 1
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 470 mg/kg soil dw
Additional information
Famoxadone was tested in one earthworm study with a resultant 14-day LC50 of 815 ppm.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.