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EC number: 247-074-2 | CAS number: 25524-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 March 2019 - 02 May 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 5.05 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 3.2 - <= 4
- Remarks on result:
- other: It must be stated that the results overall indicated that the test item is easily prone to hydrolysis.
- Details on results:
- As the test item is a liquid, the flask shaking test was performed.
Due to the definitive test samples indicating extensive hydrolysis, it was decided to modify the procedure and prepare additional samples with reduced contact times.
On completion of the equilibration period, the preliminary and definitive test samples were clear and colorless with no definite excess test item present. However, the additional samples did contain a definite excess of undissolved test item. The solutions were decanted, avoiding excess test item prior to centrifugation. After centrifugation, each supernatant was taken for analysis. Each supernatant was visually observed to be clear, colorless and free from undissolved test item.
For the additional samples, all three individual water solubility results were within ± 15% of the mean, thus satisfying the criteria specified in the guidelines.
However, it must be stated that the results overall indicated that the test item is easily prone to hydrolysis.
As the test item contains an internal ester group (within the lactone ring), it was considered that the hydrolysis noted would most likely, be a ring-opening, ester-type hydrolysis reaction, yielding 5-hydroxy-dece-7-noic acid, which would be much more polar than the parent test item and therefore elute at or near the dead time. - Conclusions:
- The water solubility of the test item has been determined to be 5.05 g/L of solution at 20.0 ± 0.5 °C.
However, it must be stated that the results overall indicated that the test item is easily prone to hydrolysis.
Reference
The mean peakareas relating to the standard and sample solutions are shown in the following table:
Table 3
Solution |
Mean PeakArea |
Standard 507 mg/L |
4.6313 x 106 |
Standard 512 mg/L |
4.6751 x 106 |
Matrix blank |
None detected |
Sample 1A |
5.5777 x 106 |
Sample 1B |
5.5348 x 106 |
Sample 2A |
3.9727 x 106 |
Sample 2B |
4.0241 x 106 |
Sample 3A |
3.8067 x 106 |
Sample 3B |
3.8195 x 106 |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Table 4
Sample Number |
Time Shaken at ~ 30 ºC (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
1.22 |
3.2 |
2 |
48 |
0.875 |
3.1 |
3 |
72 |
0.834 |
3.1 |
Note: All three samples indicated extensive amounts of hydrolysis product in the samples.
Additional Testing
The mean peakareas relating to the standard and sample solutions are shown in the following table:
Table 5
Solution |
Mean PeakArea |
Standard 486 mg/L |
4.4141 x 106 |
Standard 486 mg/L |
4.4681 x 106 |
Matrix blank |
None detected |
Sample 1RA |
2.2976 x 106 |
Sample 1RB |
2.2736 x 106 |
Sample 2RA |
2.3257 x 106 |
Sample 2RB |
2.2918 x 106 |
Sample 3RA |
2.3299 x 106 |
Sample 3RB |
2.3350 x 106 |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Table 6
Sample Number |
Time Shaken at ~ 30 ºC (hours) |
Time 20ºC (hours) |
Concentration (g/L) |
Solution pH |
1R |
3 |
1 |
5.00 |
3.8 |
2R |
2 |
1 |
5.05 |
4.0 |
3R |
1 |
1 |
5.11 |
4.0 |
Mean concentration: 5.05 g/L at 20.0 ± 0.5
ºC
Range: 5.00 to 5.11 g/L
Standard Deviation: 5.15 x 10-2g/L
Relative Standard Deviation: 1.02%
Also, all three samples indicated minimal amounts of hydrolysis product in the samples.
However, it must be stated that the results overall indicated that the test item is easily prone to hydrolysis.
Description of key information
The water solubility of the test item has been determined to be 5.05 g/L of solution at 20.0 ± 0.5°C.
However, it must be stated that the results overall indicated that the test item is easily prone to hydrolysis.
Key value for chemical safety assessment
- Water solubility:
- 5.05 g/L
- at the temperature of:
- 20 °C
Additional information
The determination of water solubility of Jasminlactone was carried out by the flask method. The procedure was designed to be compatible with the EC Method A.6 and the OECD test guideline 105, and was conducted in compliance with GLP.
The water solubility of the test item has been determined to be 5.05 g/L of solution at 20.0 ± 0.5°C. However, it must be stated that the results overall indicated that the test item is easily prone to hydrolysis.
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