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EC number: 850-929-8 | CAS number: 1584-79-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 August 2019 to 7 October 2019
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- (2001)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 4-Methyl-N-[[[3-(trifluoromethyl)phenyl]amino]carbonyl] benzenesulfonamide
- EC Number:
- 850-929-8
- Cas Number:
- 1584-79-8
- Molecular formula:
- C15H13F3N2O3S
- IUPAC Name:
- 4-Methyl-N-[[[3-(trifluoromethyl)phenyl]amino]carbonyl] benzenesulfonamide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
Number: 12
Age at study initiation: 7 weeks
Weight at study initiation:
1st step: 196.8g to 202.5 g
2nd step: 202.7-204.4 g
3rd step: 207.4 to 216.7
4th step: 195.2-212.9 g
Six days of quarantine/acclimatization in groups of 3 animals per cage.
After Quarantine, the animals were acclimatized under group housing of three of fewer animals per cage until group allocation. The animas were housed in a barrier system animal rooms
pellet diet: ad libitum
water: ad libitum
ENVIRONMENTAL CONDITIONS
Temperature: 21-25 °C
Rel. Hum. 40-79%
Air change per hour: 15
Photoperiod of 12 hours light per day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Rationale for the selection of the starting dose: In absence of data regarding the toxicity of the test item, 300 mg/kg bw was chosen as starting point.
- Doses:
- 1st/2nd step: 300mg/kg; 10 mL/kg
3rd/4th step: 2000 mg/kg, 10 mL/kg - No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- The animals were fasted for 17-19 hours before the administration, and for three to four hours after the administration. The administration was performed once by gavage. The administration was conducted with a syringe at the volume of 10 mL/kg based on the body weight measured on the administration day.
Duration of the observation period following administration: 14 days.
Frequency of observations and weighing: body weights were recorded on days 0 (before administration) , 7, 14, or at death, clinical signs; 10 mins, 30 mins, 1 hour, 2 hours, 3 hours, 4 hours, and 5 hours after dosing, once daily thereafter.
Necropsy of survived animals was done after 14 days, of dead animals immediately after dead. External surface of the body, all orifices, subcutis, cranial, thoracic, abdominal, and pelvic cavities with their contents were observed.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1
- Clinical signs:
- other: Adverse effects on the digestive tract and nervous system was observed. Mucous stool was observed at 300 and 2000 mg/kg. It was considered as adverse effects on the digestive tract. The effects had good reversibility.
- Gross pathology:
- In the general clinical observation, salivation, restlessness, lacrimation, decreased spontaneous locomotion, decreased respiratory rate and incomplete eyelid opening were observed mainly at 2000 mg/kg. Salivation and restlessness were considered to be caused not by irritation of the test substance but by adverse effects on the nervous system, since no findings associated with the irritability was observed in the necropsy of the dead animal. Lacrimation might be caused by the adverse effects on the nervous system. Decreased spontaneous locomotion, decreased respiratory rate and incomplete eyelid opening were caused by the adverse effects on the digestive tract and/or nervous system. Since these toxic symptoms disappeared by one day after the administration except for the dead animal, and since the body weight increase was normal seven days after the administration, the adverse effects had good reversibility.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The hazard class of the acute oral toxicity of the substance was classified to Category 5 since no mortality or moribundity occurred in any animals of the 1st or 2nd step at 300 mg/kg or 4th step at 2000 mg/kg, but one animal was dead in the 3rd step at 2000 mg/kg.
- Executive summary:
The hazard class of the acute oral toxicity of the substance was classified to Category 5 since no mortality or moribundity occurred in any animals of the 1st or 2nd step at 300 mg/kg or 4th step at 2000 mg/kg, but one animal was dead in the 3rd step at 2000 mg/kg.
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