Registration Dossier
Registration Dossier
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EC number: 686-016-4 | CAS number: 881302-73-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Minor deviation; no impact on study reliability
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 5-(dihydroxyboranyl)benzene-1,3-dicarboxylic acid
- Cas Number:
- 881302-73-4
- Molecular formula:
- C8H7BO6
- IUPAC Name:
- 5-(dihydroxyboranyl)benzene-1,3-dicarboxylic acid
- Test material form:
- solid
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- ca. 422.9 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 2 g/L
- Incubation duration:
- >= 24 - <= 96 h
- Temp.:
- 30 °C
- pH:
- ca. 3
- Remarks on result:
- other: Pre-incubation at 30°C; incubation for 24h at 20°C before analysis
Any other information on results incl. tables
After dilution the samples were injected in HPLC-MSMS according to the GLP validated method RRCo-000730_01.
Results of sampling:
Analysis date Concentration in 3.5-dicarboxybenzene boronic acid (mg/L)
01/09/2020* 427.8
02/09/2020 424.0
03/09/2020 416.8
*This sample was taken and analysed on 01/09/2020. But during the batch a vial position error was made. The vials were injected again with the batch of 02/09/2020. (Stability was proved in the study RRCo-000730_01).
The 3 samples do not differ by more than 15%. The average concentration of 3.5-dicarboxyphenyl boronic acid was 422.9 mg/L.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of test item 3.5-dicarboxyphenyl boronic acid is 422.9 mg/L.
- Executive summary:
After pre-incubation at 30°C under stirring for several hours, then 24 hours at 20°C ± 0.5°C, the maximum concentration of 3.5-dicarboxyphenyl boronic acid was determined. The solubilisation plateau is reached at a concentration mean of 422.9mg/L.
The water solubility of test item 3.5-dicarboxyphenyl boronic acid is 422.9 mg/L.
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