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Diss Factsheets
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EC number: 203-996-7 | CAS number: 112-67-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity: Fixed Dose Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Palmitoyl chloride
- EC Number:
- 203-996-7
- EC Name:
- Palmitoyl chloride
- Cas Number:
- 112-67-4
- Molecular formula:
- C16H31ClO
- IUPAC Name:
- hexadecanoyl chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Janvier Labs, France
- Age at study initiation: young adult (female approx. 9-10 weeks)
- Weight at study initiation: animals of comparable weight (+/- 20% of the mean weight)
- Housing: Makrolon cage, type III (single housing)
- Diet (e.g. ad libitum): LASQCdiet® Rod16, HiHyg, LASvendi (Altromin, 32791 Lage, Germany)
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days before experimental phase
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 3°C
- Humidity (%): 30-70 %
- Air changes (per hr): approx. 10
- Photoperiod (hrs dark / hrs light): 12/12 h
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 40cm²
- % coverage: 10%
- Type of wrap if used:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 h
- Duration of exposure:
- 24 h
- Doses:
- - 1000 mg/kg bw
(main and range finder study
- 2000 mg/kg bw (range finder study) - No. of animals per sex per dose:
- 2 (main study)
1 (range finder study) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs for each animal were recorded several times on the day of application and at least once during each workday thereafter
- Necropsy of survivors performed: yes
- Clinical signs including body weight
- Other examinations performed: clinical signs, body weight, pathology
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred in both animals.
- Clinical signs:
- other: No systemic clinical signs were observed in both animals during clinical examination. Local effects: In the first animal, moderate erythema (grade 3) was observed from study day 1 until study day 3, followed by well-defined erythema (grade 2) from study d
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in any animal examined on the last day of observation (4 females).
Any other information on results incl. tables
Range finding study
Mortality: In the first range finding study dosed with 2000 mg/kg bw, the animal was sacrificed moribund due to severe skin findings and resulting distress on day 7 after administration. No mortality occurred in the second range finding study dosed with 1000 mg/kg bw.
Systemic effects: No obvious systemic clinical signs were observed during clinical examination, but distress due to the observed skin findings must be considered.
Local effects: In the first range finding study with 2000 mg/kg bw, severe erythema (grade 4) was seen in the single animal from study day 1 until day 7, while slight edema (grade 2) was noted from study day 2 until day 7. In addition, incrustation was observed on study day 3, followed by oozing wounds from study day 6 until study day 7. In the second range finding study with 1000 mg/kg bw, the single animal showed moderate erythema (grade 3) from study day 1 until day 2, followed by well-defined erythema (grade 2) from study day 3 until day 12 and very slight erythema (grade 1) from study day 13 until 14. In addition, eczema was seen from study day 1 until study day 2, while incrustation was noted from study day 3 until study day 14. Erythema and incrustation beyond the application area were noted from study day 7 until study day 14.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the median lethal dose (LD50) of palmitoyl chloride after dermal application was assessed to be greater than 1000 mg/kg bw and lower than 2000 mg/kg bw in female rats.
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