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EC number: 456-990-3 | CAS number: 244761-29-3 LITHIUM-BIS(OXALATO)BORATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-08-18 to 2010-10-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline compliant study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 26 °C, 90 % humidity
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC Agilent
- Type: 1200
- Type, material and dimension of analytical (guard) column: Agilent TC-C18 (4.6 mm, 250 mm, 5 µm)
- Detection system: variable wavelength detector (VWD, 230 nm)
MOBILE PHASES
- Type: water/acetonitrile (35 % / 65 %)
- Solutes for dissolving test and reference substances: 0.1 g of the test substance are solved in 30 mL THF and then scaled with purity water to 100 mL resulting in a solution of 1 mg/mL concentration.
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column. Sodium nitrate was used to detect the dead time of the column.
REFERENCE SUBSTANCES
- Identity (CAS Number): Sodium nitrate (7633-99-4), Acetanilide (103-84-4), Phenol (108-95-2), Methyl benzoate (93-58-3), Naphthalene (91-20-3), Phenanthrene (85-01-8), DDT (50-29-3)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µg/mL with 10 µL injection volume
- Quantity of reference substances: same as test substance
- Intervals of calibration: no data
REPETITIONS
- Number of determinations: no data
EVALUATION
- Calculation of capacity factors k': were calculated from the retention times (tR) of the selected reference substances and the test material and the dead time (t0) using the following relation:
K´= (tR - t0) / t0
- Calculation of retention times: were not calculated but measured with HPLC.
- Determination of the log Koc value: The adsorption coefficient (Koc) is deduced from the capacity factor (K´) using a calibration plot of log K´ versus log Koc of the reference substances. The regression coefficients were determined by linear regression calculation using the least squares method:
log Koc = m*log K´+ b
This equation is showing the corresponding relationship between Koc and retention time. - Type:
- log Koc
- Value:
- ca. 1.25
- Temp.:
- 26 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: The used retention times are as follows:
Acetanilide: 3.621
Phenol: 3.783
Methyl benzoate: 5.054
Naphthalene: 7.469
Phenanthrene: 10.707
DDT: 31.066
- Details of fitted regression line (log k' vs. log Koc): y = 2.9649x + 2.4858, R2 = 0.964
- Graph of regression line attached: No
- Average retention data for test substance: The retention time of LiBOB was 3.838 min. resulting in a capacity factor K´ of 0.838 and a log Koc of 1.25. - Validity criteria fulfilled:
- not specified
- Conclusions:
- Lithium bis(oxalato)borate was assessed in an adsorption study resulting in a log Koc of 1.25 (at 26 °C).
- Executive summary:
Lithium bis(oxalato)borate (LiBOB) was assessed in an adsorption study, conducted with HPLC, according to OECD guideline 121. Acetanilide, Phenol, Methylbenzoate, Naphthalene, Phenanthrene and DDT were taken as reference substances. Sodium nitrate was used to determine the dead time of the column. The HPLC conditions were as follows:
apparatus: Agilent HPLC 1200
column: Agilent TC-C18 (4.6 mm, 250 mm, 5 µm)
mobile phase: water/acetonitrile (35%/65%)
injection volume: 10 µL
detector: VWD, 230 nm
The retention time of LiBOB was determined as 3.83 min resulting in a log Koc of 1.25 (at 26 °C). (Guizhou, 2010)
Reference
Description of key information
In accordance with column 2 of REACH Annex VIII, section 9.3.1, a study on adsorption and desorption does not need to be conducted, as the physico-chemical properties of the test substance indicate a low adsorption potential. LiBOB has a log Pow of -4.8. Nevertheless a study has been conducted with lithium bis(oxalato)borate, which resulted in a log Koc of 1.25 (at 26 °C), showing that the test substance does not likely absorb to particles and soil.
As the log Koc changes over time due to the degradation of LiBOB in water the log Koc of 1.25 from the study was not used for risk assessment.
Key value for chemical safety assessment
Additional information
Lithium bis(oxalato)borate (LiBOB) was assessed in an adsorption study, conducted with HPLC, according to OECD guideline 121. Acetanilide, Phenol, Methylbenzoate, Naphthalene, Phenanthrene and DDT were taken as reference substances. Sodium nitrate was used to determine the dead time of the column. The retention time of LiBOB was determined as 3.83 min resulting in a log Koc of 1.25 (at 26 °C). (Guizhou, 2010)
The Koc value is the ratio of the concentration of the substance in soil/sludge and the concentration of the substance in the aqueous phase at adsorption equilibrium.
Koc= c(soil) / c(water)
Both sorption processes are linked with each other and are influenced by different parameters, e.g. physico-chemical properties of the substance. As the log Koc changes over time due to the degradation of LiBOB (please refer to IUCLID section 5.2) in water the log Koc of 1.25 from the study was not used for risk assessment.
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