Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-806-9 | CAS number: 697-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTRL reports
Data source
Reference
- Reference Type:
- other: Secondary Literature
- Title:
- SKIN CORROSIVITY EVALUATION IN RABBITS FOR THE TEST CHEMICAL
- Author:
- NTRL
- Year:
- 1 982
- Bibliographic source:
- OTS0573384, last updated 09/10/82
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DOT regulation 173.1300 Appendix A – Method of Testing Corrosion to Skin (46 FR 49889, October 8. 1981, effective July 1. 1982).
- Principles of method if other than guideline:
- A study was performed in rabbits to assess the skin corrosive potential of 4-nonyl phenol
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-nonylphenol
- EC Number:
- 203-199-4
- EC Name:
- p-nonylphenol
- Cas Number:
- 104-40-5
- Molecular formula:
- C15H24O
- IUPAC Name:
- 4-nonylphenol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 4-Nonylphenol
- Molecular formula: C15H24O
- Molecular weight: 220.354 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):4-Nonylphenol
- Molecular formula : C15H24O
- Molecular weight : 220.354 g/mol
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dutchland Laboratories, Inc.
Denver, Pennsylvania
- Age at study initiation: Young adults
- Weight at study initiation: 2.5 – 3.0 kg
- Fasting period before study: No data available
- Housing: Individually housed, Suspended, stainless steel cage.
- Diet (e.g. ad libitum): Purina lab Rabbit Chow HF (#5326), ad libitum
- Water (e.g. ad libitum): automatic watering system, ad libitum Municipal water supply (Elizabethtown water Co.)
- Acclimation period: 30 days. All animals were checked for viability twice daily. Prior to assignment to study all animals were examined to ascertain their suitability for study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 60-70°F [15- 21deg C]
- Humidity (%): monitored daily
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): 12 hours light, 12 hours dark
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped and intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 48 h
- Number of animals:
- Six (3 male & 3 female)
- Details on study design:
- TEST SITE
- Area of exposure: left side of the spinal
column
- % coverage: 1inch*1inch
- Type of wrap if used: Plastic sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the test sites wiped free of excess test material with castile soap and water.
- Time after start of exposure: after 4 hours of exposure
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 48 h
- Max. score:
- 4.9
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
Irritation generally consisted of slight or very slight erythema and edema at 4 hours. At termination of the study (48 hours), however all animals exhibited evidence of corrosivity and tissue damage {necrotic skin)
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- A study was performed in 6 young adult New Zealand White albino rabbits to assess the skin corrosive potential of 4-nonyl phenol.
Irritation generally consisted of slight or very slight erythema and edema at 4 hours. At termination of the study (48 hours), however all animals exhibited evidence of corrosivity and tissue damage {necrotic skin).
The Primary Irritation Index after 48 hours was 4.9.
Based on the score and observations, 4-nonylphenol was considered to be corrosive to skin - Executive summary:
A study was performed in 6 young adult New Zealand White albino rabbitsto assess the skin corrosive potential of 4-nonyl phenol. The study was conducted according toDOT regulation 173.1300 Appendix A – Method of Testing Corrosion to Skin (46 FR 49889, October 8. 1981, and effective July 1, 1982) Guidelines. On the day before dosing the hair of each rabbit was closely clipped from the back with an electric clipper, so as to expose the back from the scapular to the lumbar region. The skin at the site remained intact; no abrasions were made. There was one test site per animal, on the left side of the spinal column. Five-tenths milliliter (0.5 ml) of p-nonyl phenol applied beneath a surgical gauze square, 1inch*1inch was placed directly on the test site and held in place with tape. Plastic sheeting was then wrapped around the animals and secured with tape to retard evaporation and keep the test substance in contact with the skin without undue pressure. Following approximately 4 hours of exposure, the wrappings and gauze squares were removed and the test si tes wiped free of excess test material with castille soap and water. Observations were made for erythema and edema or other evidence of dermal irritation or injury 30 minutes after removal of the occlusive wrapping. i.e., approximately 4.5 hours. Irritation generally consisted of slight or very slight erythema and edema at 4 hours. At termination of the study (48 hours), however all animals exhibited evidence of corrosivity and tissue damage {necrotic skin). The Primary Irritation Index after 48 hours was 4.9.
Based on the score and observations, 4-nonylphenol was considered to be corrosive to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.