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EC number: 201-126-0 | CAS number: 78-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Does not significantly accumulate in organisms.
Key value for chemical safety assessment
Additional information
According to Regulation (EC) 1907 (2006) Annex IX, Section 9.3.2, Column 2, a study on bioaccumulation does not need to be conducted as the substance has a low potential for bioaccumulation. Isophorone (CAS 78-59-1) has an experimentally determined log Kow of 1.7 (Veith, GD et al. 1980, see IUCLID Ch. 4.7). Regarding these values, accumulation of the test substance in organisms is not to be expected.
However, a publication is available from Barrows et al. 1980 (OECD SIDS 2005). The bioaccumulation potential of isophorone (CAS 78 -59 -1) was assessed in a study using bluegill sunfish (Lepomis macrochirus) as test species. No guideline was specified, however the test procedure was comparable to guideline studies. Using a test item concentration of 92.4 µg/L, the BCF was determined to be 7 L/kg (whole body w.w.).
In addition, under supervision of the Japanese Ministry of the Environment a bioaccumulation test according to OECD 305C was conducted under GLP and published in 1976. The test species was Cypricus carpio. The fish were exposed for 6 weeks to nominal test concentrations of 0.5 and 0.05 mg/L. The test concentrations were analytically verified. The BCF value was determined to be in the range between 1.1 and 1.8 L/kg (concentration does: 0.5 mg/L, NITE, 1976).
In conclusion, based on the measured low logKow and the results of the publication by Barrows et al. (1980) supproted by the results from an OECD 305C study (NITE, 1976), isophorone does not significantly accumulate in organisms.
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