Registration Dossier
Registration Dossier
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EC number: 402-730-9 | CAS number: 54914-85-1 KS-232
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- other: reference to SNIF-file
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FDA-Methode (Federal Register Vol. 38, Nr. 187 (27.09.73) 1500.42) und Draize und Kelley- Methode (Drug Cosm. Ind. 71 (1952) 36)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-bis(3-methylphenoxy)ethane
- EC Number:
- 402-730-9
- EC Name:
- 1,2-bis(3-methylphenoxy)ethane
- Cas Number:
- 54914-85-1
- Molecular formula:
- C16H18O2
- IUPAC Name:
- 1-methyl-3-[2-(3-methylphenoxy)ethoxy]benzene
- Test material form:
- solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Remarks:
- according to CLP criteria
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Remarks:
- according to CLP criteria
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.25
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Remarks:
- according to CLP criteria
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 1
- Remarks on result:
- no indication of irritation
- Remarks:
- according to CLP criteria
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance caused slight eye irritation effects in a study according to the Draize method. Classification according to CLP criteria is not warrent.
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