Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 447-750-9 | CAS number: 807618-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 March 2004 - 08 April 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-methylresorcinol
- EC Number:
- 207-984-2
- EC Name:
- 5-methylresorcinol
- Cas Number:
- 504-15-4
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 5-methylbenzene-1,3-diol
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- benzene-1,3-diol
- Reference substance name:
- 2,5-dimethylresorcinol
- EC Number:
- 207-688-3
- EC Name:
- 2,5-dimethylresorcinol
- Cas Number:
- 488-87-9
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 2,5-dimethylbenzene-1,3-diol
- Reference substance name:
- 2-methylresorcinol
- EC Number:
- 210-155-8
- EC Name:
- 2-methylresorcinol
- Cas Number:
- 608-25-3
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 2-methylbenzene-1,3-diol
- Reference substance name:
- 4-methylresorcinol
- EC Number:
- 207-827-8
- EC Name:
- 4-methylresorcinol
- Cas Number:
- 496-73-1
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 4-methylbenzene-1,3-diol
- Reference substance name:
- 4,5-dimethylbenzene-1,3-diol
- EC Number:
- 610-895-5
- Cas Number:
- 527-55-9
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 4,5-dimethylbenzene-1,3-diol
- Reference substance name:
- 5-ethylbenzene-1,3-diol
- Cas Number:
- 4299-72-3
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 5-ethylbenzene-1,3-diol
- Reference substance name:
- 2-ethyl-5-methylbenzene-1,3-diol
- Cas Number:
- 27465-63-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2-ethyl-5-methylbenzene-1,3-diol
- Reference substance name:
- 5-ethyl-2-methylbenzene-1,3-diol
- Cas Number:
- 34745-52-3
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 5-ethyl-2-methylbenzene-1,3-diol
- Reference substance name:
- 2,4,5-trimethylbenzene-1,3-diol
- Cas Number:
- 20427-81-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2,4,5-trimethylbenzene-1,3-diol
- Reference substance name:
- 2,4-dimethylresorcinol
- EC Number:
- 211-213-5
- EC Name:
- 2,4-dimethylresorcinol
- Cas Number:
- 634-65-1
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 2,4-dimethylbenzene-1,3-diol
- Reference substance name:
- Phenol
- EC Number:
- 203-632-7
- EC Name:
- Phenol
- Cas Number:
- 108-95-2
- Molecular formula:
- C6H6O
- IUPAC Name:
- phenol
- Reference substance name:
- Cresol
- EC Number:
- 215-293-2
- EC Name:
- Cresol
- Cas Number:
- 1319-77-3
- Molecular formula:
- C7H8O
- IUPAC Name:
- cresol
- Reference substance name:
- not applicable
- Molecular formula:
- not applicable
- IUPAC Name:
- not applicable
- Test material form:
- liquid
- Details on test material:
- Sponsor's identification: Total shale oil phenols
Description: dark brown extremely viscous liquiy
Batch number: Part No. 3
Date received: 30 January 2004
Storage conditions: room temperature, in the dark
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
Constituent 10
Constituent 11
Constituent 12
Constituent 13
Constituent 14
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- One New Zealand White rabbit was supplied by David Percival Ltd, Moston, Sandbach, Cheshire, UK. At the start of the study the animal was in the weight range of 2.0 to 3.5 kg and was twelve to twenty weeks old. After an acclimatisation period of at least five days the animal was given a number unique within the study which was written with a black indelible marker-pen on the inner surface of the ear and on the cage label.
The animal was individually housed in a suspended metal cage. Free access to mains drinking
water and food (Certified Rabbit Diet (Code 5322) supplied by BCM IPS Limited, London, UK)
was allowed throughout the study. The diet and drinking water were considered not to contain
any contaminant of a level that might have affected the purpose or integrity of the study.
The temperature and relative humidity were set to achieve limits of 17 to 23°C and 30 to 70%
respectively. Any occasional deviations from these targets were considered not to have affected
the purpose or integrity of the study. The rate of air exchange was at least fifteen changes per
hour and the lighting was controlled by a time switch to give twelve hours continuous light (06:00
to 18:00) and twelve hours darkness.
The animal was provided with environmental enrichment items which were considered not to
contain any contaminant of a level that might have affected the purpose or integrity of the study.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 mL of test substance
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hour, 24 hours, 48 hours, 72 hours, 7 days, 14 days
- Number of animals:
- 1
- Details on study design:
- On the day before the test the rabbit was clipped free of fur from the dorsal/flank area using veterinary clippers. Only animals with a healthy intact epidermis by gross observation were
selected for the study. One rabbit was treated. Three suitable sites were selected on the back of the rabbit. At each test site a quantity of 0.5 ml of the test material was introduced under a 2.5 cm x 2.5 cm cotton gauze patch and placed in position on the shorn skin. Each patch was secured in position with a strip of surgical adhesive tape. To prevent the animal interfering with the patches, the trunk of the rabbit was wrapped in an elasticated corset and the animal was returned to its cage for the duration of the exposure period.
One patch was removed at each of three time points: 3 minutes, 1 hour and 4 hours after application. Any residual test material was removed by gentle swabbing with cotton wool soaked in 74% Industrial Methylated Spirits.
After consideration of the skin reactions produced in the first animal, no further animals were treated.
Approximately one hour following the removal of the patches, and 24, 48 and 72 hours later, the test sites were examined for evidence of primary irritation anf scored according to the following scale:
EVALUATION OF SKIN REACTIONS
Erythema and Eschar Formation Value
No erythema: 0
Very slight erythema (barely perceptible): 1
Well-defined erythema: 2
Moderate to severe erythema: 3
Severe erythema (beef redness) to eschar formation preventing grading of erythema: 4
Oedema Formation Value
NO edema: 0
Very slight oedema (barely perceptible): 1
Slight oedema (edges of area well-defined by definite raising): 2
Moderate oedema (raised approximately 1 millimetre): 3
Severe oedema (raised more than | millimetre and extending beyond the area of EXPOSULE): 4
Any other skin reactions, if present, were also recorded.
Additional observations were made on Days 7 and 14 to assess the reversibility of skin reactions.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: dark brown-coloures dermal necrosis over whole of treatment site
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- Unable to score for erythema due to dark brown-coloured staining and blanching
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- Unable to score for erythema due to dark brown-coloured staining and blanching
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: oedema extending ventrally below treatment site
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- Adverse reaction prevent evluation of oedema
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- Adverse reaction prevent evluation of oedema
Any other information on results incl. tables
Dark brown-coloured staining was noted at the treated skin site throughout the study.
Dark brown-coloured staining and blanching of the skin, both of which prevented evaluation of erythema, were noted at the treated skin site one hour after patch removal. Well-defined erythema around the treated skin site was also noted one hour after patch removal. Dark brown-coloured dermal necrosis (attributed a Draize score of 4 for injuries in depth), light brown discolouration of the epidermis, loss of skin elasticity and flexibility and well-defined erythema surrounding other skin reactions were noted at the treated skin site at the 24-hour observation. A hardened dark brown/black-coloured scab, undulating in appearance, was noted at the treated skin site at the 48, 72-hour and 7 and 14-day observations with well-defined erythema surrounding other skin reactions also noted at the 48-hour observation and scab lifting to reveal glossy skin also noted at the 14-day observation.
Moderate oedema was noted at the treated skin site one hour after patch removal with severe oedema, extending ventrally below the treatment site, at the 24-hour observation.
The reactions noted at the treated skin site at the 48-hour and subsequent observations prevented the evaluation of erythema and oedema.
The reactions were considered to be indicative of dermal corrosion.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Executive summary:
A single 4-hour, semi-occluded application of the test material to the intact skin of one rabbit produced reactions indicative of dermal corrosion including blanching of the skin, well- defined erythema surrounding treatment site, dark brown necrosis, hardened dark brown/black-coloured scabs, scabs lifting to reveal glossy skin, scab undulating, loss of skin elasticity and flexibility and oedema extending ventrally below treatment site. On occasions the reactions noted precluded the evaluation of erythema and oedema.
Conclusion:
The test material was classified as corrosive to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.