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EC number: 806-801-9 | CAS number: 1539267-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 December 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- yes
- Remarks:
- (see "Principles of method if other than guideline" for details)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 30 May 2008
- Deviations:
- yes
- Remarks:
- (see "Principles of method if other than guideline" for details)
- Principles of method if other than guideline:
- Due to the test material characteristics, the exact guideline text could not be followed; but the main objectives were met.
Because the test material is unstable in ultrapure water and the estimated water solubility is low (around 1 mg/L), an UV absorption method (using spectrophotometer) was used for the determination of the water solubility rapidly after mixing, to reduce the impact of degradation on the result. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: UV absorption method
- Specific details on test material used for the study:
- No correction for purity of the test material was applied.
- Key result
- Water solubility:
- > 1 - < 10 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- Remarks on result:
- other: Information on pH not reported.
- Details on results:
- - Results of the Method Validation
Selectivity: No interfering component was observed.
Repeatability: RSD = 1.5 %
Linera range: 0.01 – 2 µg/mL
Limit of Quantification: 0.01 µg/mL
Recovery of the test material from ultrapure water (1 mg/L): 89 %
Precision in ultrapure water medium (1 mg/L): 1.3 %
Stability of the test material in ultrapure water (2 and 3 days, saturated solution), Recovery %: 67 and 50 % - therefore unstable.
Stability of the samples: At least 32 hours in the autosampler.
Stock solution stability at 5 ± 3 °C: Prepare fresh daily.
Main study results
The approximate water solubility was determined based on the above method.
In case of the reference solutions, clear solutions were detected in each case (before and after filtration). During the visual checking by a Tyndall beam laser, there were no remaining particles.
In case of the test material solutions, the laser beam was visible before filtration, indicating the test material was not totally dissolved. However, clear solutions were detected after filtration when checking by Tyndall beam, there were no remaining particles.
The recorded spectra of the formulations within 190 – 600 nm wavelength range showed that the water solubility was clearly a lot less than 10 mg/L and slightly higher than 1 mg/L. - Conclusions:
- The water solubility of the test material was determined to be less than 10 mg/L and higher than 1 mg/L at approximately 20 °C using a UV absorption method.
- Executive summary:
The water solublity of the test material was investigated under GLP conditions, using an UV absorption method.
Under the conditions of the study, the water solubility of the test material was determined to be less than 10 mg/L and higher than 1 mg/L at approximately 20 °C.
Reference
Description of key information
The water solublity of the test material was investigated under GLP conditions, using an UV absorption method.
Under the conditions of the study, the water solubility of the test material was determined to be less than 10 mg/L and higher than 1 mg/L at approximately 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 1 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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