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Diss Factsheets
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EC number: 700-867-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-10-22 to 2002-03-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission, Document ECB/TM/February 1996: "Particle Size Distribution Fibre Length and Diameter Distribution", Guidance Document using the laser diffraction method.
- Deviations:
- no
- Remarks:
- There were no circumstances that may have affected the quality or integrity of the data.
- Principles of method if other than guideline:
- The above mentioned guideline contains several different methods for the determination of the particle size distribution. These are, between others sieving, microscopic examination, sedimentation, gravitational settling examination, cascade impaction and laser scattering / diffraction. In the present study the laser scattering / diffraction was applied.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate from the Swiss GLP monitoring Authority.
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- - Batch n°: RT002102G4A311
- Analytical purity: 99.4%
- Expiration date: 25 March 2002
- Storage condition: at room temperature - Percentile:
- other: D5
- Mean:
- 0.7 µm
- St. dev.:
- 0.03
- Percentile:
- D10
- Mean:
- 0.9 µm
- St. dev.:
- 0.061
- Percentile:
- D50
- Mean:
- 2.8 µm
- St. dev.:
- 0.148
- Percentile:
- D90
- Mean:
- 8.3 µm
- St. dev.:
- 0.41
- Conclusions:
- The particle size of T002102 was found to range from about 0.5 µm to 175 µm using the laser diffraction apparatus (range between 0.3 µm and 300 µm). The mass median diameter (MMD) was determined to be 2.8 µm.
Reference
Visual examination (magnification 400) showed small colourless, crystalline structures.
Table 1. Percentage of the test substance T002102 particles below 1, 5 and 10 um as relevant particle size for the human health (exposure via inhalation).
um | 1. Run% | 2. Run% | 3. Run % | 4. Run% | Mean % | Stand. Dev |
<1.0 | 10.47 | 12.60 | 10.20 | 13.11 | 11.60 | 1.47 |
<5.0 | 75.00 | 75.35 | 74.61 | 75.65 | 75.15 | 0.45 |
<10 | 94.12 | 92.34 | 94.70 | 92.14 | 93.33 | 1.28 |
Description of key information
The particle size distribution of the substance was determined in a GLP study performed according to European Commission, Document ECB/TM/February 1996: "Particle Size Distribution Fibre Length and Diameter Distribution", Guidance Document using the laser diffraction method without deviations (Tognucci, 2002). This K1 study concludes that the particle size of the substance ranges between 0.5 and 175 µm, with a median mass diameter of 2.8 µm.
Additional information
The GLP study of Tognucci (2002) to determine the particle size distribution of T002102 according to the test guideline of the European Commision ECB/TM/February 1996 "Particle Size Distribution, Fibre Length and Diameter Distribution" concluded that the mass median diameter (MMD) was 2.8 µm using the laser diffraction apparatus in the range between 0.3 µm and 300 µm. The particle size distribution ranged from approximately 0.5 µm to 175 µm.
This study is considered reliable (Klimisch 1) and assigned as key study for this endpoint.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.