Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-162-9 | CAS number: 557-21-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For that endpoint, two reliable studies to assess skin irritation and corrosion in vivo and eye irritation in vivo on the registered substance were available. These studies were performed according to the OECD Guideline 404 (Acute Dermal Irritation / Corrosion) and OECD Guideline 405 (Acute Eye Irritation / Corrosion).
Regarding skin irritation/corrosion, under the experimental conditions, no skin reaction was observed with "Zinc cyanide batch n°10185145 " exposure. Therefore, "Zinc cyanide batch n°10185145" induced no dermal irritaiton in male New Zealand White rabbits and was considered to be a non-irritant.
Concerning eye irritation, under the experimental conditions, the Index of Acute Ocular Irritation (IAOA) of Zinc cyanide batch n°10185145 was calculated to be "4.7". Therefore, Zinc cyanide batch n°10185145 is not classified as eye irritant based on GHS criteria.
The validity criteria were successful and the study was therefore regarded as acceptable for that endpoint.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- ENVIRONMENTAL CONDITIONS: the animal room environment was automatically controlled according to KIT SOPs(target range: temperature 20±3°C, relative humidity 30-70%, approximatly 12 hours light/ 12 hours dark cycle with 150-300 Lux, and ventilation 10-20 times/hour). Temperature and relative humidity were monitored continuously. Animal room and cage cleaning was performed according to KIT SOPs. Cage card and animal room use record were attached on the cage and the entrance of the animal room, respectively.
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.5g
- Observation period:
- 1, 24, 48 and 72 hours
- Number of animals:
- 3
- Irritation parameter:
- erythema score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No dermal irritation was observed at 1, 24, 48, 72 hours after test item application
- Other effects:
- Test item-related death or abnormal general clinical signs were not observed during the study period.
Test item-related body weight changes were not observed. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- To investigate dermal irritation of the test item, Zinc cyanide was administered by dermal at dose of 0.5 g/head for 4 hours in 3 male New Zealand White rabbits. Mortality, clinical signs, body weight change and local irritation were observed until 72 hours after test item. No clinical sign, body weight, dead animaln or abnormal skin reaction considered to be due to test item were observed. In conclusion Zinc cyanide induced no dermal irritaiton in male New Zealand White rabbits and was considered to be a non-irritant.
- Executive summary:
For that endpoint, one reliable study to assess skin irritation and corrosion in vivo on the registered substance on New Zealand White rabbits was available. The study was performed according to the OECD Guideline 404 (Acute Dermal Irritation / Corrosion).
Under the experimental conditions, no skin reaction was observed with "Zinc cyanide batch n°10185145 " exposure. Therefore, "Zinc cyanide batch n°10185145" induced no dermal irritaiton in male New Zealand White rabbits and was considered to be a non-irritant.
The validity criteria were successful and the study was therefore regarded as acceptable for that endpoint.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: Yac:NZW(KBL)
- Details on test animals or tissues and environmental conditions:
- The animal room environment was automatically controlled according to KIT SOPs (target range: temperature 20+/- 3°C, relative humidity 30-70%, approximately 12 hours light/12 hours dark cycle with 150-300 Lux, and ventilation 10-20 times/hour). Temperature and relative humidity were monitored continuously. Animal room and cage cleaning was performed according to KIT SOPs.
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- Not specified (1 application)
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- To evaluate the eye irritation/corrosion of Zinc cyanide, 0.1g of the test item was applied in 3 healthy male New Zealand white rabbits. Mortality, clinical signs, body weight changes and eye response were measured during 72 hours after application.
- Irritation parameter:
- other: mean index of ocular irritation
- Time point:
- 24/48/72 h
- Score:
- 1.85
- Max. score:
- 4.7
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Irritant / corrosive response data:
- As a result of observation the application site until 72 hours after application of the test item, no abnormalities were observed in the cornea and iris of all animals. As a result of observation for redness, chemosis and discharge in the conjunctivia, slight redness, chemosis and discharge were observed due to the test item application.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on these results, the Index of Acute Ocular Irritation (IAOA) of the test item was calculated to be "4.7". According to the classification method for eye irritants, the test item was considered to be a minimal irritant.
- Executive summary:
For that endpoint, one reliable study to assess eye irritation in vivo on the registered substance on rabbits was available. The study was performed according to the OECD Guideline 405 (Acute Eye Irritation / Corrosion).
Under the experimental conditions, the Index of Acute Ocular Irritation (IAOA) of Zinc cyanide batch n°10185145 was was calculated to be "4.7". Therefore, Zinc cyanide batch n°10185145 is not classified as eye irritant based on GHS criteria.
The validity criteria were successful and the study was therefore regarded as acceptable for that endpoint.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.