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EC number: 443-800-9 | CAS number: 40031-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Version / remarks:
- EEC Directive 92/69, Publication No. L383 Part C-3 adopted December, 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- OECD guideline No. 201 , Adopted June 7, 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 8692 (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum)
- Version / remarks:
- ISO Standard 8692, First edition, 15 November 1989
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- NA
- Analytical monitoring:
- yes
- Details on sampling:
- Frequency: at t=24 h and t= 72h
Volume: 10 mL - Vehicle:
- yes
- Details on test solutions:
- Preparation of test solutions started with a stock solution of 100 mg/l. No special treatment other than a 10-minute period of magnetic stirring was necessary to dissolve the test substance in the test medium. The lower test concentrations were prepared by subsequent dilutions of the stock in test medium. The final test solutions were all clear and colourless.
After preparation, volumes of 50 ml were added to each replicate of the respective test concentration. Subsequently, adequate volumes of an algal suspension were added to each replicate providing a cell density of 10^4 cells/ml. - Test organisms (species):
- Selenastrum sp.
- Details on test organisms:
- Selenastrum capricornutum, strain: NIVA CHL 1
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Post exposure observation period:
- NA
- Hardness:
- Hardness (Ca+Mg) 0.24 mmol/l (24 mg CaCO3)
- Test temperature:
- 21-25°C, constant within 2°C.
- pH:
- pH: 8.3 ± 0.2
- Dissolved oxygen:
- NA
- Salinity:
- NA
- Conductivity:
- NA
- Nominal and measured concentrations:
- The concentrations measured in samples taken from 100 mg/l were in agreement with nominal at the start and after 24 hours of exposure. At the end of the test period the measured concentration had decreased to 80 mg/l, i.e. by 18% relative to the initial start concentration. The measured concentration in samples taken from 100 mg/l without algae showed that the concentration remained stable during the test period. Hence, the slight decrease in the solution with algae was expected to be due to absorption to algal cells. All results will be based on nominal concentrations.
- Details on test conditions:
- NA
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Results with reference substance (positive control):
- Algae were exposed for a period of 72 hours to K2Cr207 concentrations of 0.18, 0.32, 0.56, 1.0, 1.8 and 3.2 mg/l and to a blank-control. The initial cell density was 1.0 x 10^4 cells/ml. Under the conditions of the reference study with Selenastrum capricornutum, potassium dichromate inhibited cell growth of this fresh water algae species at nominal concentrations of 0.56 mg/l and higher and reduced growth rate at 1.0 mg/l and higher.
- Validity criteria fulfilled:
- yes
- Conclusions:
- No inhibition of cell growth or reduction of growth rate was recorded at any of the concentrations of (S)-1,3,4-trihydroxybutan-2-one tested.
Hence, the EC50 for both cell growth inhibition and growth rate reduction was above 100 mg/l, the regulatory limit concentration. - Executive summary:
No inhibition of cell growth or reduction of growth rate was recorded at any of the concentrations of (S)-1,3,4-trihydroxybutan-2-one tested.
Hence, the EC50 for both cell growth inhibition and growth rate reduction was above 100 mg/l, the regulatory limit concentration.
Reference
No remarks
Description of key information
No inhibition of cell growth or reduction of growth rate was recorded at any of the concentrations of (S)-1,3,4-trihydroxybutan-2-one tested.
Hence, the EC50 for both cell growth inhibition and growth rate reduction was above 100 mg/l, the regulatory limit concentration.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
Additional information
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