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EC number: 214-379-7 | CAS number: 1123-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963 - 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Adaptation of the repeated insult patch test procedure suggested by Draize (Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, published 1959 by The Association of Food and Drug Officials of the United States, p. 52).
- Version / remarks:
- 1959
- Deviations:
- no
- Principles of method if other than guideline:
- The test procedure was an adaptation of the repeated insult patch test procedure suggested by Draize (Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, published 1959 by The Association of Food and Drug Officials of the United States, p. 52).
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-phenylpropan-1-ol
- EC Number:
- 214-379-7
- EC Name:
- 2-phenylpropan-1-ol
- Cas Number:
- 1123-85-9
- Molecular formula:
- C9H12O
- IUPAC Name:
- 2-phenylpropan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: humans (37 volunteers)
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL of 6.25% hydratropic alcohol in water
- Duration of treatment / exposure:
- 9 applications every other day over a period of 20 days, 24 hours each
- Observation period:
- 20 days in total, starting from first application
- Number of animals:
- 37 volunteers finished the study (43 volunteers at start)
- Details on study design:
- The test patch was a one-inch square of Webril (absorbent non-woven cotton fabric) affixed to the center of a 1 x 3-inch strip of adhesive elastic bandage material. The test bandages were specially prepared by Duke Laboratories, Inc. Immediately before application to each subject 0.5 mL of sample was added to the Webril swatch and the bandage was then placed on the subject's upper arm. Six to nine different samples were tested simultaneously on each group of subjects, and the order in which they were applied was rotated from one subject to the next. The subjects removed the bandages 2h hours after application.
(Early in the test program a large number of subjects was similarly tested with 95% ethanol on similar test patches, and a smaller number was tested with similar samples and with alcohol applied under closed patches. The results of these experiments, which are the subject of a separate report, demonstrated that closed patch exposures caused frequent strong reactions, even to alcohol alone, and that alcohol on the semi-open test patch adapted caused essentially no irritation.)
The basic schedule for the large number of tests in the program of which this is a part comprised a series of nine 2h-hour exposures on a Monday-Wednesday-Friday sequence for three successive weeks, the reaction to each exposure being scored at the session following and the reaction to the ninth application on Monday of the fourth week. The test patch was applied to the same site each time, unless reaction to sample or tape adhesive rendered this inadvisable, in which case the test patch was either omitted or applied to a fresh site. On Monday of the sixth week a challenge patch was applied to a site not previously exposed, and removed after 2h hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- 37 volunteers assessed
- Time point:
- other: 20 days
- Score:
- >= 0 - <= 1
- Max. score:
- 6
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 37 volunteers assessed
- Time point:
- 48 h
- Score:
- < 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- scoring was performed every second day for 20 days.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- scoring was performed every second day for 20 days.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 37 volunteers assessed
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- scoring was performed every second day for 20 days.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- scoring was performed every second day for 20 days.
- Irritant / corrosive response data:
- Under the conditions of this-test Sample SJ 1286-H caused little or no primary irritation.
Any other information on results incl. tables
Individual reaction scores and group totals for each scoring session are shown in Table I. In this Table the numeral column headings refer to applications as numbered in the preceding section. The columns A and A' designate first and second scorings of the challenge.
Symbols other than scores appearing among the data have the following meanings:
M: Applied to second site after a strong test reaction.
M-1: Applied to third site after second strong test reaction.
R: Applied to second site because of tape reaction or for other reason irrelevant to test.
S: Returned to original site after an "R" move.
M-R: Moved once because of test reaction and once for other reasons.
X: Not applied because of test reaction.
XR: Not applied for reasons irrelevant to test.
L: Test patch lost soon after application.
Sm: "Small" patch, using reduced amount of sample for safety.
-: Subject absent.
*: Residual reaction to earlier application, after an absence, not included in score totals.
( ): Flaring or persistent reactions on sites not patched at preceding session, reported only when of special interest.
N.P.: Number of subjects not included in score totals (X, XR, L, -, *).
Subjects 10, 12, 24 and 86 were tested with closed patches for the first three applications, with the regular semi-Open patches thereafter.
Individual scores of experiments
Subject |
application scores |
challenge scores |
|||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
A |
A' |
|
10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
XR |
XR |
- |
- |
XR |
0 |
0 |
0 |
0 |
0 |
50 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
64 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
86 |
0 |
0 |
R 0 |
R 0 |
R 0 |
S 0 |
0 |
0 |
0 |
1 |
- |
1D |
0 |
0 |
0 |
0 |
0 |
- |
* 0 |
0 |
0 |
0 |
0 |
9D |
0 |
0 |
0 |
R 0 |
- |
* R 0 |
S 0 |
0 |
0 |
0 |
- |
16D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
26D |
0 |
0 |
0 |
1 |
R 0 |
S 0 |
0 |
0 |
0 |
0 |
0 |
29D |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
42D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
45D |
0 |
0 |
0 |
R 0 |
R 0 |
S 0 |
0 |
0 |
0 |
0 |
0 |
46D |
0 |
0 |
0 |
R 0 |
R 0 |
- |
* R 0 |
S 0 |
0 |
0 |
0 |
48D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
65D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
72D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
73D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
91D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
118D |
0 |
0 |
0 |
0 |
- |
* 0 |
0 |
0 |
0 |
0 |
0 |
122D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
130D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
134D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
0 |
0 |
136D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
139D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
152D |
0 |
- |
* 0 |
0 |
0 |
0 |
0 |
0 |
R 0 |
0 |
0 |
154D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
173D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
174D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
176D |
0 |
0 |
0 |
0 |
- |
* 0 |
0 |
0 |
0 |
0 |
0 |
182D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
183D |
0 |
- |
*0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
188D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
189D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
190D |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Totals score 0 |
37 |
33 |
34 |
34 |
33 |
31 |
35 |
37 |
35 |
36 |
32 |
Totals score 1 |
0 |
1 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
N.P. |
0 |
3 |
3 |
1 |
4 |
6 |
2 |
0 |
1 |
0 |
5 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this-test Sample SJ 1286-H caused little or no primary irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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