5-(3-Phenylpropioloyl)-1,3-isobenzofurandione

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24-06-2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

ISO 13320:2009 “Particle Size Analysis – Laser Diffraction Methods”, 2009

Deviations:

no

GLP compliance:

yes

Type of method:

Laser scattering/diffraction

Type of particle tested:

agglomerate

Type of distribution:

volumetric distribution

Specific details on test material used for the study:

No further details specified in the study report

Mass median aerodynamic diameter:

21.231 µm

Geometric standard deviation:

2.275

Key result

Percentile:

D10

Mean:

8.33 µm

St. dev.:

0.008

Key result

Percentile:

D50

Mean:

18.7 µm

St. dev.:

0.024

Key result

Percentile:

D90

Mean:

37.2 µm

St. dev.:

0.118

No.:

#1

Size:

< 10 µm

Distribution:

14.71 %

During the method development phase of the analysis trials were conducted using the small volume (wet) module (SVM) only. The SVM trials were conducted using kerosene as the dispersant. The results of these trials indicated that the most appropriate test and material parameters to obtain the optimum measurements were:

Module: SVM

Dispersant: Kerosene

Dispersion speed: 1700 rpm

Refractive index (sample): 0.000n

Absorption: 0.000 AU

Analysis Model: General Purpose

 

Using the identified parameters, the particle size was analysed over the range 0.01 μm to 3500 μm.

 

Full Test Results

	Run 1	Run 2	Run 3	Run 4	Run 5	Average	STDVP	% STDVP
VWM	23.8	23.8	23.6	23.9	24.4	23.9	N/A	N/A
Mode	19.7	19.6	19.6	19.6	19.6	19.6	N/A	N/A
d10	8.34	8.33	8.32	8.33	8.34	8.33	0.00778	0.0934
d50 (Median)	18.8	18.8	18.7	18.7	18.7	18.7	0.0241	0.129
d90	37.1	37.2	37.0	37.1	37.3	37.2	0.118	0.318
MMAD	21.262	21.255	21.196	21.216	21.227	21.231	0.025	0.1
GSD	2.269	2.272	2.264	2.276	2.297	2.275	0.011	0.5

All particle size results are in µm

 

14.71% by volume of sample was seen to be <10.00 µm

 

Definitions

VWM: volume weighted mean

d10: 10% of the test item is less than this particle size

d50: 50% of the test item is less than this particle size

d90: 90% of the test item in less than this particle size

GSD: geometric standard deviation of the lognormal particle size distribution

MMAD: mass median aerodynamic diameter

Average: calculated from the entirety of the data captured in each run and not a simple arithmetic mean

STDVP: standard deviation of the population

% STDVP: percentage standard deviation of the population

 

The coefficient of variation for d50 is less than 3%; d10 and d90 are less than 5%. Thus repeatability of the characteristic particles in the size distribution is within the acceptable limits as per the ISO 13320-1 test standard.

Conclusions:

14.71% by volume of sample was seen to be <10.00 µm

Executive summary:

 

Particle Size Analysis using small volume (wet) module (SVM)	Average (µm)
Volume weighted mean	23.9
Median (d50)	18.7
Mode	19.6
MMAD (Mass Median Aerodynamic Diameter)	21.231
10% of material is <	8.33
50% of material is <	18.7
90% of material is <	37.2
By volume of sample was seen to be < 10.00 µm	14.71%

 

Description of key information

 

Particle Size Analysis using small volume (wet) module (SVM)	Average (µm)
Volume weighted mean	23.9
Median (d50)	18.7
Mode	19.6
MMAD (Mass Median Aerodynamic Diameter)	21.231
10% of material is <	8.33
50% of material is <	18.7
90% of material is <	37.2
By volume of sample was seen to be < 10.00 µm	14.71%