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EC number: 204-635-6 | CAS number: 123-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20001-09-10 to 2001-05-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Non GLP study and limited data reported but conducted according to ÖNORM EN ISO.
- Qualifier:
- according to guideline
- Guideline:
- other: ÖNORM EN ISO6314
- Version / remarks:
- (06/96; 05/99)
- Principles of method if other than guideline:
- Deviation to the EC and OECD guidelines on acute daphnia testing: no chemical analysis was performed, exposition 24 h instead of 48 h, no details about statistical analysis, chosen concentrations do not reflect a dose response curve; the specing factor is not the same between the chosen concentrations.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Details on sampling:
- not applicable
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test item was diluted in deionised water (Millipore ELIX 10) and the pH was adjusted with diluted NaOH and H2SO4 to 7.8 +/- 0.2. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia mangna STRAUS
- Age at study initiation: 1-24h - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- no data
- Hardness:
- no data
- Test temperature:
- 20 +/- 2 °C
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentrations:
- Preliminary test: Control, 5, 10, 15, 20, 30 and 40 g/L
- Main experiment: Control, 10, 11, 12, 13, 14, and 15 g/L - Details on test conditions:
- TEST SYSTEM
- No. of organisms per vessel: not stated in the report, but according to ÖNORM EN ISO 6341 at least 20 Daphnia have to be used per concentration in the main experiment.
- No. of vessels per concentration: preliminary experiment: 2; main experiment 4
- No. of vessels per control: preliminary experiment: 2; main experiment 4
OTHER TEST CONDITIONS
- Adjustment of pH: yes, the test item was diluted in deionised water (Millipore ELIX 10) and the pH was adjusted with diluted NaOH and H2SO4 to 7.8 +/- 0.2.
- Photoperiod: the test was conducted in the dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Range finding study, test concentrations: control, 0.01, 0.10 and 0.50 mg/L
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 5 - <= 15 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: not reported
- Other biological observations: not reported
- Mortality of control: no
- Other adverse effects control: not reported
- Abnormal responses: in the main experiment slight scattered immobilisation occurred in the concentrations tested (10, 11, 12 , 13 , 14 and 15 g/L), as the range of the concentrations tested is very close this scattered immobilisation is deemed as biological variance.
- Any observations that might cause a difference between measured and nominal values: not reported
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- An acute Daphnia test according to ÖNORM EN ISO 6341 was conducted. The EC50, 24 h for Succinimide was determined to be between 5-15 g/L.
- Executive summary:
The 24–hr-acute toxicity of succinimide to Daphnia magna was studied under static conditions. Test species were exposed to control, and test chemical at nominal concentration of 10, 11, 12, 13, 14, and 15 g/L for 24 hr. Immobilisation was observed at test termination. The test was conducted according to ÖNORM EN ISO 6341.
The 24-hr EC50could not be determined in the main test. As in the range finder no immobilisation was observed for an exposure concentration of 5 g/L it is assumed in the test report that the 50 % effect concentration must be between 5 to 10 g/L.
The study report contains only limited data and the study design deviates from OECD guideline 202 recommendations. Nevertheless, the range finder of the study shows that no immobility occurs among daphnia exposed to succinimide at 5 g/L for 24 hr. This concentration is far above the concentration relevant to classification. Results from the main test scattered without revealing a dose-response (see table 1), therefore a concrete EC50 could not be derived in the present test, but is assumed to be between 5 to 10 g/L.
Based on the results of this study, a classification in accordance with the classification system of CLP is not applicable.
Results Synopsis
Test Organism Age (e.g. 1stinstar): not reported
Test Type (Flowthrough, Static, Static Renewal): Static
EC50: 5 to 10 g/L
NOEL: 5 g/L (result from range finding test)
Endpoint(s) Effected: immobility
Reference
Table 1: test results
|
Concentration (g/L): |
|||||||||||
date: |
test character: |
0 |
5 |
10 |
11 |
12 |
13 |
14 |
15 |
20 |
30 |
40 |
Immobilisation (%): |
||||||||||||
2001-11-14 |
preliminary |
0 |
0 |
20 |
- |
- |
- |
- |
100 |
100 |
100 |
100 |
2001-11-20 |
main |
0 |
- |
70 |
80 |
40 |
45 |
65 |
55 |
- |
- |
- |
Description of key information
An acute Daphnia test according to ÖNORM EN ISO 6341 was conducted.
The EC50, 24 h for succinimide was determined to be between 5 to 15 g/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5 g/L
Additional information
A study according to ÖNORM EN ISO6314 is available assessing the toxicity of succinimide towards Daphnia magna for 24 h.
In a conservative approach the lower value from the experimentally determined range (5 to 15 g/L) was chosen as EC50 value for assessment.
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