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Diss Factsheets
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EC number: 209-984-8 | CAS number: 600-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Desmutagenic effect of α-dicarbonyl and α-hydroxycarbonyl compounds against mutagenic heterocyclic amines
- Author:
- Kim, S.B., Hayase F, and Kato H.,
- Year:
- 1 987
- Bibliographic source:
- EFSA Journal, 12(11):3888
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- Only TA100 used without metabolic activation
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Pentane-2,3-dione
- EC Number:
- 209-984-8
- EC Name:
- Pentane-2,3-dione
- Cas Number:
- 600-14-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,3-dione
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
2,3-pentanedione purchased from Nakarai Chemicals Ltd, Kyoto
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 1.05 µmole
No justification of the top dose provided - Vehicle / solvent:
- No information provided
Controls
- Positive controls:
- yes
- Positive control substance:
- 2-acetylaminofluorene
- benzo(a)pyrene
- Details on test system and experimental conditions:
- Prior to preincubation, 150 µl of each aqueous solution containing 0.37 nmole Trp-P-1, 0.39 nmole Trp-P-2, 0.40 nmole Glu-P-1, 4.53 nmoles Glu-P-2, 0.02
nmole IQ were allowed to react with and without 150 µl of each aqueous solution containing 4.44 µmoles α-hydroxycarbonyls and 1.05 µmoles α-dicarbonyls
at 121°C for 20 min. respectively, and 100 µl of each resulting reaction mixture were used for the mutagenicity test.
The initial pH of the reaction mixture was 7.0. - Rationale for test conditions:
- No information provided
- Evaluation criteria:
- Desmutagenicity was expressed as the ratio of the percentage of the mutagenicity of each mutagenic heterocyclic amine before and after the addition of the test substance.
- Statistics:
- No information provided
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- not determinable because of methodological limitations
Applicant's summary and conclusion
- Conclusions:
- The test chemical was negative for mutagenicity in S typhimurium TA100 without metabolic activation under the conditions of the study.
- Executive summary:
The test chemical was tested for mutagenicity in S typhimurium TA100 without metabolic activation. Under the conditions of the study the test substance was negative.
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