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EC number: 425-450-9 | CAS number: 294-90-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test.
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.14 (Ames-Test)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 425-450-9
- EC Name:
- -
- Cas Number:
- 294-90-6
- Molecular formula:
- C8H20N4
- IUPAC Name:
- 1,4,7,10-tetraazacyclododecane
- Test material form:
- not specified
- Details on test material:
- - Substance name: 1,4,7,10-tetraazacyclododecane
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- Not applicable
- Additional strain / cell type characteristics:
- not specified
- Cytokinesis block (if used):
- Not used
- Metabolic activation:
- with and without
- Metabolic activation system:
- "DEUSTCH" Leberhomogenat von mit Aroclor 1254 behandelten Ratten. "ENGLISH" Liver homgenat from Aroclor 1254 treated rats.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 3 ... 3330 μg/plateConcentration range in the main test (without metabolic activation): 3 ... 3330 μg/plate
- Vehicle / solvent:
- Solvent: DMSO
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 1000 μg/plate)
- Key result
- Species / strain:
- other: As specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 1000 μg/plate)
- Key result
- Species / strain:
- other: As specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 1000 μg/plate)
- Additional information on results:
- None
- Remarks on result:
- other: Preliminary test
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, the test substance is not mutagenic in the tested TA 98,100, 1535 and 1537 Salmonella typhimurium strains.
- Executive summary:
The test substance mutagenicity study was performed according to the 92/69/EWG, B.14 (Ames-Test) Guideline under GLP conditions.
Several concentrations of test substance ranging from [3 -3330 μg/plate] were tested in TA 98,100, 1535 and 1537 Salmonella typhimurium strains with and without metabolic activation ( Liver homgenat from Aroclor 1254 treated rats ).
Under the test conditions, the test substance is not mutagenic in the tested TA 98,100, 1535 and 1537 Salmonella typhimurium strains with and without metabolic activation. Test substance caused cytotoxic effect at concentrations >1000µg/plate.
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