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EC number: 283-922-8 | CAS number: 84775-98-4 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Satureja hortensis, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
- Justification for type of information:
- An in vitro skin corrosion study of Summer Savory oil: Reconstructed human epidermis (RhE) test method has been performed. According to the test results the substance Summer Savory oil fulfils the criteria for classification as Skin Corrosion Sub Category 1B/1C.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Reference
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 April 2019 – 23 June 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- Version / remarks:
- OECD Guideline 431 Adopted 29 July 2016
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- EssentÍal oil of Summer Savory/batch No. SSVI.ES.sample
Date of manufacture: 08.01.2019
Expration date of the batch: 08.01.2021
UVCB substance;
Purity test date: 18.01.2019 - Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Cell source:
- other: Three-dimensional RhE models are obtained commercially (epiCS® supplied by CellSystems®). Additionally, 2 killed Human skin model surfaces were treated (SkinEthic RHE® model) in the same manner in order to generate non-specific MTT reduction.
- Source strain:
- other: human
- Justification for test system used:
- According to Annex VII of REACH Regulation, if new test data is required those must be derived from in vitro methods only.
Human skin models (epiCS®, SkinEthic™) (OECD 431) are accepted in vitro test method to detect skin corrosion/irritation (Category 1 or 2) and/or the absence of effects (not classified under CLP). - Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent no treatment
- other: Four killed control tissue models (two by exposure time) were added to the study, which underwent the entire testing procedure to generate a non-specific MTT reduction control.
- Amount/concentration applied:
- Preliminary test
The direct interaction of MTT with the test item was checked by adding 50 µL of the test item to 1 mL of the solution of MTT at 1 mg/mL (same conditions as in the main test). The preparation turned into two phases, one being yellow and one being purple, after 1 hour of incubation between 37.1°C and 37.4°C, 5% CO2.
As two phases appeared with a coloured part, direct interaction with MTT could be masked.
That is why four killed control tissue models (two by exposition time) were added to the study, which underwent the entire testing procedure to generate a non-specific MTT reduction control.
Main test
50 µL of the test item as supplied on 0.6 cm² human skin model
50 µL for positive control 8N KOH– Fisher Scientific
50 µL for negative control of distilled water– ADL Prochilab. - Duration of treatment / exposure:
- 3 minutes and 1 hour for test material
3 minutes and 1 hour for negative and positive control - Duration of post-treatment incubation (if applicable):
- During 3 minutes at room temperature
During 1 hour at 370 C ± 10 C, 5%CO2 - Number of replicates:
- Two tissue replicates.
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 3 minutes and 1 hour after the test item application
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Corrosion
- Other effects / acceptance of results:
- This study is classified as acceptable and satisfies the requirement for Test Guideline OECD 431 for in vitro skin corrosion: Reconstructed human epidermis (RhE) test method.
Acceptability criteria:
The difference of viability between the 2 tissues treated with the negative control during 3 minutes was higher than 30% (40.9%).
Considering the results obtained (both epidermises have a viability much higher than 50% and are clearly classified as “Non-corrosive”), this deviation is considered as without impact on the conclusion of the study. - Interpretation of results:
- other: Corrosive sub-category 1B/1C
- Conclusions:
- In accordance with the Regulation (EC) No. 1272/2008, the results obtained under the test conditions enable to conclude that the test item Summer Savory oil has to be classified in Sub Category 1B/1C “Corrosive” according to the Regulation (EC)1272/2008.
The corresponding hazard statement is “H314: Causes severe skin burns and eye damage”. - Executive summary:
The aim of the study was to evaluate the possible corrosive effects of the test item Summer Savory oil after topical administration on in vitro human reconstituted epidermis (epiCS®, CellSystems®).
The test item Summer Savory oil was applied as supplied, at the dose of 50 µL, to two tissue Human skin model surfaces (epiCS®, CellSystems®) during 3 minutes and 1 hour. The application was followed by a rinse with 20 mL of DPBS. Cell viability was then measured by enzymatic conversion of the vital dye MTT into a blue formazan salt that was quantitatively measured after extraction from tissues.
Additionally, 2 killed Human skin model surfaces were treated (SkinEthic RHE® model) in the same manner in order to generate non-specific MTT reduction.
The experimental protocol was established in accordance with the OECD. Test Guideline No. 431 dated 29 July 2016 and the EU method Method B.40.bis. In vitro skin corrosion: Human skin model test of the Council Regulation No. 440/2008 dated 30 May 2008.
3 minutes and 1 hour after the test item application, the mean percent viability of the epidermis skins treated with the test item was 23.14% and 18.66%, versus 19.17% and 0.41%, respectively, with the positive control item (potassium hydroxide 8N).
In accordance with the Regulation (EC) No. 1272/2008, the results obtained under the test conditions enable to conclude that the test item Summer Savory oil has to be classified in Sub Category 1B/1C “Corrosive” according to the Regulation (EC)1272/2008.
The corresponding hazard statement H314: Causes severe skin burns and eye damage” has to be assigned.
ASSESSMENT OF THE SKIN CORROSION
INDIVIDUAL AND AVERAGE VALUES AFTER 3 MINUTES EXPOSURE
TEST ITEM: Summer Savory oil
Application: 50 μL of the test item as supplied on 0.6 cm² human skin model
Application date: 16 May 2019
Table 1
|
Well ID |
OD |
Mean OD / disc (#) |
Mean OD / product
|
Viability, %
|
Mean Viability, %
|
Viability difference between replicates, %
|
Negative control |
SPL 1
SPL 2 |
0.716 0.704 0.719
0.456 0.461 0.494 |
0.713
0.471
|
0.592 |
120.44
79.56 |
100.00 |
40.9 |
Positive control |
SPL 3
SPL 4
|
0.100 0.116 0.131
0.106 0.110 0.115 |
0.116
0.111 |
0.114 |
19.59
18.75 |
19.17 |
0.8 |
Test item PH-19/0208 |
SPL7
SPL8 |
0.240 0.241 0.245
0.190 0.218 0.220 |
0.242
0.210 |
0.0226 |
40.88
35.47 |
38.18 |
5.4 |
Test item PH-19/0208 NSMTT |
SPL7
SPL8
|
0.084 0.089 0.094
0.088 0.091 0.087 |
0.089
0.089 |
0.089 |
15.03
15.03 |
15.03 |
0.0 |
Test item PH-19/0208 corrected |
|
|
|
|
|
23.14 |
|
Note
#: mean of 3 values
OD: optical density
SPL: sample
Acceptability criteria:
- Negative control: mean OD of the tissue replicates should be ≥ 0.8 and ≤ 2.8 for epiCS® model, for every exposure time. As the extract was diluted at 1:3 just before the OD measure, the acceptability criteria should be in the range ≥ 0.3 and ≤ 0.9 for the negative control.
- Positive control: mean viability of the tissue replicates exposed for 1 hour, expressed as % of the negative control, should be < 20% for epiCS model.
- Test item: in the range 20-100% viability, and for ODs ≥ 0.3, difference of viability between the two tissue replicates should not exceed 30%.
ASSESSMENT OF THE SKIN CORROSION
INDIVIDUAL AND AVERAGE VALUES AFTER 1 HOUR EXPOSURE
TEST ITEM: Summer Savory oil
Application: 50 µL of the test item as supplied on 0.6 cm² human skin model
Application date: 16 May 2019
Table 2
|
Well ID |
OD |
Mean OD / disc (#) |
Mean OD / product
|
Viability, %
|
Mean Viability, %
|
Viability difference between replicates, %
|
Negative control |
SPL 11
SPL 12 |
0.667 0.832 0.807
0.653 0.664 0.730 |
0.769
0.683 |
0.726 |
105.92
94.08 |
100.00 |
11.8 |
Positive control |
SPL 13
SPL 14 |
0.002 0.000 0.001
0.005 0.005 0.005 |
0.001
0.005 |
0.003 |
0.14
0.69 |
0.41 |
0.6 |
Test item PH-19/0208 |
SPL 17
SPL 18 |
0.194 0.204 0.207
0.187 0.191 0.195 |
0.202
0.191 |
0.197 |
27.82
26.31 |
27.07 |
1.5 |
Test item PH-189/0208 NSMTT |
SPL 19
SPL 20 |
0.063 0.059 0.062
0.061 0.056 0.062 |
0.062
0.060 |
0.061 |
8.54
8.26 |
8.40 |
0.3 |
Test item PH-19/0208 corrected |
|
|
|
|
|
18.66
|
|
Note
#: mean of 3 values
OD: optical density
SPL: sample
Acceptability criteria:
- Negative control: mean OD of the tissue replicates should be ≥ 0.8 and ≤ 2.8 for epiCS® model, for every exposure time. As the extract was diluted at 1:3 just before the OD measure, the acceptability criteria should be in the range ≥ 0.3 and ≤ 0.9 for the negative control.
- Positive control: mean viability of the tissue replicates exposed for 1 hour, expressed as % of the negative control, should be < 20% for epiCS model.
- Test item: in the range 20-100% viability, and for ODs ≥ 0.3, difference of viability between the two tissue replicates should not exceed 30%.
ASSESSMENT OF THE SKIN CORROSION
CONCLUSION AFTER 3 MINUTES AND AFTER 1 HOUR EXPOSURE
TEST ITEM: Summer Savory oil
Application: 50 μL of the test item as supplied on 0.6 cm² human skin model
Application date: 16 May 2019
Table 3
|
Mean viability (%) |
||
|
3 min exposure |
1 hour exposure |
Conclusion |
Positive control |
19.17 |
0.41 |
Corrosive sub-category 1B/1C |
Test item PH-19/0208 |
23.14 |
18.66 |
Corrosive sub-category 1B/1C |
Note
The item is to be classified as non-corrosive:
-If the viability after 3 minutes’ exposure is greater than or equal to 50% and the viability after 1-hour exposure is greater than or equal to 15 %;
The item is to be classified as corrosive:
- If the viability after 3 minutes’ exposure is strictly less than 50%, or
- If the viability after 3 minutes’ exposure is greater than or equal to 50% and the viability after 1-hour exposure is strictly less than 15 %
Summary of Negative Control data after a treatment of 3 minutes
Date |
Negative control item |
Replicate num1ber |
OD |
Mean OD |
Viability (%) |
Viability difference between replicates (%) |
10/01/2018 |
Distilled water |
1
2 |
0.578
0.562 |
0.570 |
101.4
98.6 |
2.8 |
24/01/2018 |
Distilled water |
1
2 |
0.710
0.750 |
0.730 |
97.26
102.74 |
5.5 |
21/02/2018 |
Distilled water |
1
2 |
0.686
0.695 |
0.691 |
99.35
100.65 |
1.3 |
21/03/2018 |
Distilled water |
1
2 |
0.667
0.805 |
0.736 |
90.63
109.38 |
18.8 |
05/04/2018 |
Distilled water |
1
2 |
0.655
0.637 |
0.646 |
101.39
98.61 |
2.8 |
11/04/2018 |
Distilled water |
1
2 |
0.787
0.643 |
0.715 |
110.07
89.93 |
20.1 |
23/05/2018 |
Distilled water |
1
2 |
0.821
0.669 |
0.745 |
110.2
89.80 |
20.4 |
04/07/2018 |
Distilled water |
1
2 |
0.649
0.641 |
0.645 |
100.62
99.38 |
1.2 |
08/08/2018 |
Distilled water |
1
2 |
0.476
0.464 |
0.470 |
101.28
98.72 |
2.6 |
05/09/2018 |
Distilled water |
1
2 |
0.570
0.727 |
0.649 |
87.90
112.10 |
24.2 |
10/10/2018 |
Distilled water |
1
2 |
0.629
0.616 |
0.623 |
101.04
98.96 |
2.1 |
17/10/2018 |
Distilled water |
1
2 |
0.612
0.635 |
0.624 |
98.16
101.84 |
3.70 |
05/12/2018 |
Distilled water |
1
2 |
0.722
0.636 |
0.679 |
106.33
93.67 |
12.70 |
OD: optical density
Negative control item = Dulbecco's phosphate-buffered saline (DPBS) or distilled water.
The optical density was measured after a dilution of the extractions in isopropanol (1:3).
Summary of Negative Control data after a treatment of 1 hour
Date |
Negative control item |
Replicate number |
OD |
Mean OD |
Viability (%) |
Viability difference between replicates (%) |
10/01/2018 |
Distilled water |
1
2 |
0.772
0.604 |
0.688 |
112.21
87.79 |
24.4 |
24/01/2018 |
Distilled water |
1
2 |
0.793
0.652 |
0.723 |
109.76
90.24 |
19.5 |
05/12/2018 |
Distilled water |
7
8 |
0.655
0.668 |
0.662 |
99.02
100.98 |
2.0 |
21/03/2018 |
Distilled water |
7
8 |
0.583
0.563 |
0.573 |
101.75
98.25 |
3.5 |
05/04/2018 |
Distilled water |
9
10 |
0.640
0.656 |
0.648 |
98.77
101.23 |
2.5 |
11/04/2018 |
Distilled water |
9
10 |
0.662
0.765 |
0.714 |
92.78
107.22 |
14.4 |
23/05/2018 |
Distilled water |
9
10 |
0.713
0.830 |
0.772 |
92.42
107.58 |
15.2 |
04/07/2018 |
Distilled water |
11
12 |
0.679
0.682 |
0.681 |
99.78
100.22 |
0.4 |
08/08/2018 |
Distilled water |
15
16 |
0.455
0.457 |
0.456 |
99.78
100.22 |
0.4 |
05/09/2018 |
Distilled water |
13
14 |
0.694
0.676 |
0.685 |
101.31
98.69 |
2.6 |
10/10/2018 |
Distilled water |
7
8 |
0.683
0.634 |
0.659 |
103.72
96.28 |
7.4 |
17/10/2018 |
Distilled water |
9
10 |
0.719
0.764 |
0.742 |
96.97
103.03 |
6.1 |
OD: optical density
Negative control item = Dulbecco's phosphate-buffered saline (DPBS) or distilled water.
The optical density was measured after a dilution of the extractions in isopropanol (1:3).
Summary of Positive Control data after a treatment of 3 minutes
Date |
Positive control item |
Replicate number |
OD |
Mean OD |
Viability (%) |
Viability difference between replicates (%) |
10/01/2018 |
KOH 8N |
3
4 |
0.046
0.185 |
0.116 |
8.07
32.46 |
24.4 |
24/01/2018 |
KOH 8N |
3
4 |
0.562
0.420 |
0.491 |
76.99
57.53 |
19.5 |
21/02/2018 |
KOH 8N |
3
4 |
0.025
0.059 |
0.042 |
3.62
8.54 |
4.9 |
21/03/2018 |
KOH 8N |
3
4 |
0.048
0.033 |
0.041 |
6.52
4.48 |
2.0 |
05/04/2018 |
KOH 8N |
3
4 |
0.030
0.036 |
0.033 |
4.64
5.57 |
0.9 |
11/04/2018 |
KOH 8N |
3
4 |
0.034
0.041 |
0.038 |
4.76
5.73 |
1.0 |
23/05/2018 |
KOH 8N |
3
4 |
0.144
0.244 |
0.194 |
19.33
32.75 |
13.4 |
04/07/2018 |
KOH 8N |
3
4 |
0.044
0.041 |
0.043 |
6.82
6.36 |
0.5 |
08/08/2018 |
KOH 8N |
3
4 |
0.035
0.042 |
0.039 |
7.45
8.94 |
1.5 |
05/09/2018 |
KOH 8N |
3
4 |
0.001
0.003 |
0.002 |
0.15
0.46 |
0.3 |
10/10/2018 |
KOH 8N |
3
4 |
0.260
0.154 |
0.207 |
41.77
24.74 |
17.0 |
17/10/2018 |
KOH 8N |
3
4 |
0.055
0.054 |
0.055 |
8.82
8.66 |
0.2 |
05/12/2018 |
KOH 8N |
3
4 |
0.050
0.226 |
0.138 |
7.36
33.28 |
25.9 |
OD: optical density
Positive control item = 8N potassium hydroxide.
The optical density was measured after a dilution of the extractions in isopropanol (1:3).
Summary of Positive Control data after a treatment of 1 hour
Date |
Positive control item |
Replicate number |
OD |
Mean OD |
Viability (%) |
Viability difference between replicates (%) |
10/01/2018 |
KOH 8N |
3
4 |
0.001
-0.001 |
0.0001 |
0.15
-0.15 |
0.3 |
24/01/2018 |
KOH 8N |
3
4 |
0.009
0.008 |
0.009 |
1.25
1.11 |
0.1 |
21/02/2018 |
KOH 8N |
17
18 |
0.004
0.002 |
0.003 |
0.52
0.26 |
0.3 |
21/03/2018 |
KOH 8N |
9
10 |
0.001
0.002 |
0.002 |
0.17
0.35 |
0.2 |
05/04/2018 |
KOH 8N |
11
12 |
0.003
0.004 |
0.004 |
0.46
0.62 |
0.2 |
11/04/2018 |
KOH 8N |
11
12 |
0.002
0.004 |
0.003 |
0.28
0.56 |
0.3 |
23/05/2018 |
KOH 8N |
11
12 |
0.003
0.003 |
0.003 |
0.39
0.39 |
0.0 |
04/07/2018 |
KOH 8N |
13
14 |
0.009
0.015 |
0.012 |
1.32
2.20 |
0.9 |
08/08/2018 |
KOH 8N |
17
18 |
0.003
0.003 |
0.003 |
0.66
0.66 |
0.0 |
05/09/2018 |
KOH 8N |
15
16 |
0.007
0.005 |
0.006 |
1.02
0.73 |
0.3 |
10/10/2018 |
KOH 8N |
9
10 |
0.000
0.000 |
0.000 |
0.00
0.00 |
0.0 |
17/10/2018 |
KOH 8N |
11
12 |
0.002
0.001 |
0.002 |
0.27
0.13 |
0.10 |
05/12/2018 |
KOH 8N |
9
10 |
0.001
0.002 |
0.002 |
0.15
0.3 |
0.20 |
OD: optical density
Positive control item = 8N potassium hydroxide.
The optical density was measured after a dilution of the extractions in isopropanol (1:3).
Additionally, 2 killed Human skin model surfaces were treated (SkinEthic RHE® model) in the same manner in order to generate non-specific MTT reduction.
The aim of the study was to evaluate the possible corrosive effects of the test item Summer Savory oil after topical administration on in vitro human reconstituted epidermis (epiCS®, CellSystems®).
The test item Summer Savory oil was applied as supplied, at the dose of 50 µL, to two tissue Human skin model surfaces (epiCS®, CellSystems®) during 3 minutes and 1 hour. The application was followed by a rinse with 20 mL of DPBS. Cell viability was then measured by enzymatic conversion of the vital dye MTT into a blue formazan salt that was quantitatively measured after extraction from tissues.
Additionally, 2 killed Human skin model surfaces were treated (SkinEthic RHE® model) in the same manner in order to generate non-specific MTT reduction.
The experimental protocol was established in accordance with the OECD. Test Guideline No. 431 dated 29 July 2016 and the EU method Method B.40.bis. In vitro skin corrosion: Human skin model test of the Council Regulation No. 440/2008 dated 30 May 2008.
Three minutes and 1 hour after the test item application, the mean percent viability of the epidermis skins treated with the test item was 23.14% and 18.66%, versus 19.17% and 0.41%, respectively, with the positive control item (potassium hydroxide 8N).
In accordance with the Regulation (EC) No. 1272/2008, the results obtained under the test conditions enable to conclude that the test item Summer Savory oil has to be classified in Sub Category 1B/1C “Corrosive” according to the Regulation (EC)1272/2008.
The corresponding hazard statement H314: Causes severe skin burns and eye damage” has to be assigned.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Savory, Satureja hortensis, ext.
- EC Number:
- 283-922-8
- EC Name:
- Savory, Satureja hortensis, ext.
- Cas Number:
- 84775-98-4
- IUPAC Name:
- Essential oil of Savory, Satureja hortensis, obtained from whole, dried herb by steam distillation
- Test material form:
- liquid
1
- Specific details on test material used for the study:
- EssentÍal oil of Summer Savory/batch No. SSVI.ES.sample
Date of manufacture: 08.01.2019
Expration date of the batch: 08.01.2021
UVCB substance;
Purity test date: 18.01.2019
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The Summer savory oil is classified as Serious eye damage, Category 1.
- Executive summary:
On the basis of the results of an in vitro test for skin corrosion: Reconstructed human epidermis(RhE)) test method (OECD guideline 431) and according to the classification criteria of Regulation (EC) 1272/2008, the Summer Savory oil is classified as Skin corrosion, sub-category 1B/1C.The study for Serious eye damage/eye irritation does not need to be conducted since the substance is classified as skin corrosion, which leads to classification as serious eye damage (Category 1).
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