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EC number: 427-900-1 | CAS number: 198404-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 October, 2019 - 18 November, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 22 January, 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 30 May, 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC Method
- Specific details on test material used for the study:
- JAVANOL :
Batch No. : VE00594779
Purity : 91.9% (sum of the two isomers)
Expiry Date : 04 March, 2021 - Radiolabelling:
- no
- Test temperature:
- The determination was performed at 25 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log KOC values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way.
- Details on study design: HPLC method:
- Principle of the method :
Reverse phase High Performance Liquid Chromatography on cyanopropyl-modified silica stationary phase, containing lipophilic and polar moieties, is used.
While passing through the column among with the mobile phase the test substance interacts with the stationary phase. As a result of the partitioning between the mobile and stationary phase the test substance is retarded. The dual-composition of the stationary phase having polar and non-polar sites allows for interaction of polar and non-polar groups of a molecule in a similar way as it is the case for organic matter in soil or sewage sludge matrices. This enables the relationship between the retention time on the column and the adsorption coefficient on organic matter to be established.
Equipment and conditions :
HPLC equipment: Perkin Elmer (series 200) HPLC system comprising:
- a high pressure pump (module N2910102, serial number: 291N8051901A)
- an auto-sampler (module N2930100, serial number: 293N8052404A)
- a column compartment (module N2601581, serial number: OVH0802151130)
- a refractive index detector (series 200a, serial number 125829).
- Column : 250 mm x 4.6 mm, Nucleodur 100-5 CN-RP
(Macherey-Nagel)
serial number: E15120578, batch 34514011
- Mobile phase : methanol / water 55/45 (v/v)
- Flow rate : 1.0 ml/min.
- Column temperature : 25 °C
- Injected volume : 100 µL
Reference substances :
Six substances were chosen having log KOC ranging from 1.45 to 5.63. Formamide is used as an unretained compound for the determination of the "dead time" t0.
On the day of the determination a calibration mixture of these seven substances in methanol / water 55/45 (v/v) was prepared.
Reference Substance LogKoc
Formamide dead-time
2-Nitrobenzamide 1.45
Methyl Benzoate 1.80
Naphthalene 2.75
1,2,3-Trichlorobenzene 3.16
Phenanthrene 4.09
4,4'-DDT 5.63 - Key result
- Sample No.:
- #1
- Type:
- log Koc
- Remarks:
- HPLC Method
- Value:
- 3.8 L/kg
- Temp.:
- 25 °C
- Matrix:
- HPLC Method
- Sample No.:
- #2
- Type:
- log Koc
- Value:
- 3.8
- Temp.:
- 25 °C
- Matrix:
- HPLC Method
- Details on results (HPLC method):
- The chromatograms of Javanol show one main peak (~99.4% rel. peak area) at an average retention time of 9.488 minutes, corresponding to an adsorption coefficient (log value) of 3.8, and one minor peak (~0.6% rel. peak area) at an average retention time of 14.668 minutes, corresponding to an adsorption coefficient (log value) of 4.5.
Therefore: Adsorption coefficients (KOC) of Javanol:
log Koc = 3.8 (main peak)
A further minor peak (representing 0.6% of relative surface area) was observed to have a LogKoc of 4.5. - Validity criteria fulfilled:
- yes
- Conclusions:
- The chromatograms of Javanol show one main peak (~99.4% rel. peak area) at an average retention time of 9.488 minutes, corresponding to an adsorption coefficient (log value) of 3.8, and one minor peak (~0.6% rel. peak area) at an average retention time of 14.668 minutes, corresponding to an adsorption coefficient (log value) of 4.5.
Therefore: Adsorption coefficients (KOC) of Javanol:
log Koc = 3.8 (main peak)
A further minor peak (representing 0.6% of relative surface area) was observed to have a LogKoc of 4.5.
Reference
Description of key information
The Log Koc for JAVANOL is 3.8.
This value of Log Koc suggests strong sorption to soil and sediment, negligible to slow migration potential to groundwater.
.
Key value for chemical safety assessment
- Koc at 20 °C:
- 6 310
Additional information
The Log Koc for JAVANOL is 3.8.
This value of Log Koc suggests strong sorption to soil and sediment, negligible to slow migration potential to groundwater.
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