Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 429-040-0 | CAS number: 272460-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 April 2019 - 15 July 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187: Particle Size Analysis by Laser Diffraction, Handbook K.
- Version / remarks:
- 2007
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Remarks:
- Laser Diffraction Analysis, using the medium volume (wet) module (MVM)
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- Specific details on test material used for the study:
- Physical Description: Off-white powder
Storage Conditions: At room temperature protected from light desiccated
Purity/Composition correction factor: No correction factor required
Test item handling: Use amber glassware or wrap container in aluminum foil
Chemical name: 1-{4-[(4-benzoylphenyl)sulfanyl]phenyl}-2-methyl-2-(4-methylbenzenesulfonyl)propan-1-one
CAS number: 272460-97-6
EC Number: 429-040-0
Molecular weight: 515 - Mass median aerodynamic diameter:
- 6.2 µm
- Geometric standard deviation:
- 9.976
- Percentile:
- D10
- Mean:
- 0.106 µm
- St. dev.:
- 0.001
- Percentile:
- D50
- Mean:
- 5.34 µm
- St. dev.:
- 0.101
- Percentile:
- D90
- Mean:
- 90.6 µm
- St. dev.:
- 1.71
- Conclusions:
- The particle size distribution of the test item was determined by means of Laser Diffraction Analysis using the medium volume (wet) module (MVM).
The D50 of the test item was determined to be 5.34 µm, the D10 was 0.106 µm and the D90 was 90.6 µm. The MMAD of the test item was calculated to be 6.20 µm. - Executive summary:
The objective of this study was to determine the particle size distribution of Esacure 1001 M.
The summary of the results is listed below:
Particle Size Analysis using medium volume (wet) module (MVM) Average (µm) Volume weighted mean 29.8 Mode 3.01 D10 (10% of material is <) 0.106 D50 (50% of material is <) 5.34 D90 (90% of material is <) 90.6 MMAD (mass median aerodynamic diameter) 6.2 Volume of sample <10.00 µm 0.61% (<9.86 µm) The particle size distribution of the test item was determined by means of Laser Diffraction Analysis using the medium volume (wet) module (MVM).
The D50 of the test item was determined to be 5.34 µm, the D10 was 0.106 µm and the D90 was 90.6 µm. The MMAD of the test item was calculated to be 6.20 µm.
Reference
Solubility and Dispersability Test
Preliminary test
The results of the preliminary test to select a suitable dispersant are given below:
Solvent used | Soluble (Yes/No) | Comments |
Milli-Ro water | No | floats on the surface |
2-Propanol | No | Well dispersed |
Cyclohexane | No | Well dispersed |
Methanol | No | Well dispersed |
Polyethyleneglycol 300 | No | poor dispersability |
2-Propanol and methanol were identified as suitable dispersants, as the substance visually did not dissolve, and because it was homogenously and there was no tendency to agglomerate formation dispersed.
Main Test
In the preliminary test, the substance was concluded to be visually insoluble in the dispersant, thus only dispersability was investigated in the main test. The result of the main test are given below:
Dispersability in 2-Propanol
Test 1 (1.5 mg) | Test 2 (5.0 mg) | |||
Time elapsed | 1 | 2 | 1 | 2 |
10 seconds | Well dispersed | Well dispersed | ||
30 minutes | Well dispersed | Well dispersed | ||
60 minutes | Well dispersed | Well dispersed | ||
90 minutes | Well dispersed | Well dispersed |
Dispersability in Methanol
Test 1 (1.5 mg) | Test 2 (5.0 mg) | |||
Time elapsed | 1 | 2 | 1 | 2 |
10 seconds | Well dispersed | Well dispersed | ||
30 minutes | Well dispersed | Well dispersed | ||
60 minutes | Well dispersed | Well dispersed | ||
90 minutes | Well dispersed | Well dispersed |
The test item proved to be homogeneously and well dispersed in both 2-propanol and methanol. 2-Propanol was used as the dispersant in the Laser Diffraction Analysis.
Particle Size Distribution by Laser Diffraction Analysis
The particle size distribution of the test item was analysed over the range 0.01 µm to 3500 µm.
The results of the analysis are presented below. A graph of volume fraction (%) versus particle diameter (µm) and the full particle size distribution list is provide in the attached illustration (average of 5 runs).
Run 1 | Run 2 | Run 3 | Run 4 | Run 5 | Mean | STDVP | %STDVP | |
Volume weighted mean | 30.2 | 29.9 | 28.8 | 30.3 | 29.6 | 29.8 | 0.603 | 2.03 |
Mode | 3.01 | 3.01 | 3.01 | 3.01 | 3.01 | 3.01 | 0.00252 | 0.0837 |
d10 (10% of material is <) | 0.107 | 0.107 | 0.106 | 0.106 | 0.106 | 0.106 | 0.000516 | 0.486 |
d50 (50% of material is <) | 5.49 | 5.37 | 5.28 | 5.36 | 5.22 | 5.34 | 0.101 | 1.89 |
d90 (90% of material is <) | 91.9 | 90.3 | 88.1 | 92.6 | 90.3 | 90.6 | 1.71 | 1.89 |
GSD | 9.987 | 9.959 | 9.894 | 10.041 | 10.001 | 9.976 | 0.055 | 0.55 |
MMAD | 6.2 |
All results are in µm.
Definitions
GSD - geometric standard deviation of the lognormal particle size distribution
MMAD - mass median aerodynamic diameter
Mean - calculated from the entirety of the data captured in each run and not a simple arithmetic mean
STDVP - standard deviation of the population
%STDVP - percentage standard deviation of the population
The coefficient of variation for d50 is less than 3%, d10 and d90 are less than 5%. It can be concluded that the repeatability of the characteristic particles in the size distribution are within the acceptable limits.
Description of key information
The particle size distribution of the test item was determined by means of Laser Diffraction Analysis using the medium volume (wet) module (MVM).
The D50 of the test item was determined to be 5.34 µm, the D10 was 0.106 µm and the D90 was 90.6 µm. The MMAD of the test item was calculated to be 6.20 µm.
Additional information
Study conducted to recognised testing guidelines with GLP certification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.