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EC number: 907-578-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Ready Biodegradability (Closed Bottle test) OECD 301D
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: A0076
- Expiration date of the lot/batch: 2021
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Ambient, in the dark
- Stability under test conditions: Stable
- Solubility and stability of the test substance in the solvent/vehicle: Stable
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: The test material was stated to be poorly soluble in water therefore a non-ionic surfactant (IGEPAL CA 630) was used to emulsify the sample.
- Final dilution of a dissolved solid, stock liquid or gel: The emulsion was gradually diluted by the addition of deionised water and then made up to volume (500ml) to give a concentration of 1.02g/l. Replicate BOD bottles were filled to absolute volume (250ml) with the test solution, prepared by addition of a 2ml/l sample stock solution to 3.5L of inoculated mineral medium to give a test concentration of 2.0mg/l.
FORM AS APPLIED IN THE TEST (if different from that of starting material) : solution
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- non-ionic surfactant (IGEPAL CA 630)
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test material was stated to be insoluble in water therefore a surfactant was used to emulsify the sample. To prepare the emulsion, 0.5008g of the test item was intimately mixed with a 0.2496g of nonionic surfactant (IGEPAL CA 630). The emulsion was gradually diluted by the addition of
deionised water and then made up to volume (500ml) to give a concentration of 1.02g/l.
- Controls:
- Inoculum blank: inoculated mineral medium
- Functional/reference control: 5.01 mg/L sodium acetate
- Toxicity control: 2.0 mg/L test Item and 5.01 mg/L reference Item (sodium acetate)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): IGEPAL CA 630 (synonym: Octylphenoxy poly(ethyleneoxy)ethanol, branched)
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)): 1.00 mg/L
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): Not reported - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Laboratory culture:
no
- Name and location of sewage treatment plant where inoculum was collected: Cambridge STW, Cowley Road, Cambridge
- Initial biomass concentration: 1 ml/l - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 28 d
- Hardness:
- Not reported
- Test temperature:
- 20.3 - 20.5oC
- pH:
- Not reported
- Dissolved oxygen:
- Control vessels
Day 0: 8.20 -8.26 mg/L
Day 7: 8.22 - 8.08 mg/L
Day 17: 7.17 - 7.87 mg/L
Day 28: 5.75 - 7.86 mg/L - Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations:
- Functional/reference control: 5.01 mg/L sodium acetate
- Toxicity control: 2.0 mg/L test Item and 5.01 mg/L reference Item (sodium acetate) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250ml BOD bottles
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: filled to absolute volume
- Biomass loading rate: 1mL/L
- Aeration: mineral medium was aerated for 20 minutes and allowed to stand for 23 hours
- No. of vessels per concentration (replicates): 11 vessels
- No. of vessels per control (replicates):11 vessels
- No. of vessels per vehicle control (replicates): 11 vessels
- No. of vessels per abiotic control (replicates): 11 vessels
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: mineral medium prepared according to OECD 301D guideline
OTHER TEST CONDITIONS
- Adjustment of pH: not reported
- Photoperiod: The bottles were incubated in the dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : dissolved oxygen measurements were used to determine material toxicity by comparing the biochemical oxygen demand (BOD) results of the test and reference vessels with that of the toxicity control vessels. The percentage degradation of the toxicity control was calculated based on the biological oxygen demand recorded. This was compared to the test and reference solutions used to make up the toxicity sample. - Reference substance (positive control):
- yes
- Remarks:
- sodium acetate
- Duration:
- 17 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: degradation of the reference material in the toxicity control conducted as a part of the biodegradation study (OECD 301D)
- Results with reference substance (positive control):
- For the reference material, sodium acetae, 88% degradation was observed after 17 days of incubation.
- Validity criteria fulfilled:
- yes
- Remarks:
- For sodium acetate 99% degradation was observed after 28 d (must be at least 60%). The maximum blank DO loss was 0.40 mg/l (must not exceed 1.5 mg/l after 28 d).
- Conclusions:
- The test item is not inhibitory to sewage treatment microorganisms at tested concentration of 2.0 mg/L.
- Executive summary:
The toxicity of the test item to activated sewage sludge was taken from the toxicity control of a GLP-compliant ready biodegradability Closed bottle test following OECD guideline 301D (Crane 2018). The results of the study show that the test item is not inhibitory to sewage treatment microorganisms at tested concentration of 2.0 mg/L. The NOEC of test item to aquatic microorganisms is 2.0 mg test item/L.
The study was conducted according to the standard guideline and is GLP-compliant, therefore is considered reliable and suitable for this endpoint.
Reference
Description of key information
The NOEC of test item to aquatic microorganisms is 2.0 mg test item/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 2 mg/L
Additional information
The toxicity of the test item to activated sewage sludge was taken from the toxicity control of a GLP-compliant ready biodegradability Closed bottle test following OECD guideline 301D (Crane 2019). The results of the study show that the test item is not inhibitory to sewage treatment microorganisms at tested concentration of 2.0 mg/L.The NOEC of test item to aquatic microorganisms is 2.0 mg test item/L.
The study was conducted according to the standard guideline and is GLP-compliant, therefore is considered reliable and suitable for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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