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EC number: 476-890-3 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 9 June 2005 to 13 September 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- yes
- Remarks:
- see below
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- yes
- Remarks:
- see below
- Principles of method if other than guideline:
- In the preliminary test, a very poor solubility in water and a good solubility in n-octanol were found indicating a partition coefficient of above 6. Hence, a main test according to OECD Guideline 107/117 (either HPLC/GC or flask shaking method) could not be applied. Therefore the partition coefficient of iron oxide isostearate was estimated using the solubility data in n-octanol from the pre-test and in water from the main test (see water solubility section).
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: partition coefficient estimated from solubilities in n-octanol and water
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: AAS
- Key result
- Type:
- log Pow
- Partition coefficient:
- 6.3
- Temp.:
- 21 °C
- Remarks on result:
- other: pH not available
- Details on results:
- The n-octanol solubility of iron oxide isostearate was determined to be 288.7 mg/mL.
As water solubility is 0.13 mg/L, the partition coefficient (LogPow) of iron oxide isostearate was calculated from the individual solubilities in n-octanol and in water, respectively, to be:
LogPow = Log10 (288673.9 mg/L / 0.13 mg/L) = 6.3 - Conclusions:
- The partition coefficient (LogPow) of iron oxide isostearate is 6.3.
- Executive summary:
The partition coefficient of iron oxide isostearate was estimated using the solubility data in n-octanol and in water (as test according to OECD Guideline 107/117 could not be applied).
The partition coefficient LogPow of iron oxide isostearate is 6.3.
Reference
Description of key information
The partition coefficient LogPow of iron oxide isostearate is 6.3.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.3
- at the temperature of:
- 21 °C
Additional information
A GLP experimental study scored as Klimisch 1, calculating the n-octanol/water partition coefficient from solubility data in n-octanol and in water, is selected as a key study and gives a n-octanol/water partition coefficient of 6.3.
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