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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 946-797-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 102 mg/m³
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Explanation for the modification of the dose descriptor starting point:
The DNEL for systemic effects via the inhalation route is determined on the basis of extrapolation of developmental effects noted in the inhalation OECD 422 study with decamethyltetrasiloxane (141-62-8). In this study a NOAEC of at least 1210 mg/m³ was derived as there were no adverse effects up to the highest dose tested. The following correction was made to the NOAEC (inhalation): Correction for exposure duration: 6 h/8 h (default for workers). Correction for respiratory rate and volume (human worker): (6.7 m³/d/10 m³/d) (default) Therefore the corrected NOAEC is: 5083*(6/8)*(6.7 m3/d /10 m³/d) = 2554 mg/m³.
- AF for dose response relationship:
- 1
- Justification:
- A clear NOAEC was established
- AF for differences in duration of exposure:
- 1
- Justification:
- Not required as developmental toxicity is not duration-specific
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (inhalation route)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default
- AF for intraspecies differences:
- 5
- Justification:
- Default
- AF for the quality of the whole database:
- 1
- Justification:
- Guideline, GLP study
- AF for remaining uncertainties:
- 2
- Justification:
- Additional assessment factor for use of screening data
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 449 mg/kg bw/day
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 144 866 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation of developmental effects noted in the inhalation OECD 422 study with decamethyltetrasiloxane (141-62-8). In this study a NOAEC of at least 5083 mg/m³ was derived as there were no adverse effects up to the highest dose tested NOAEC ≥5083 mg/m³ The following correction was made to the NOAEC (inhalation) to derive a NOAEL (dermal): Correction for exposure duration: 6h / 8h (default for workers) Correction for respiratory volume: 0.38 m³/kg (default, rat, 8 hour). Correction for dermal penetration: based on read-across from decamethyltetrasiloxane (CAS 141-62-8) dermal penetration is approximately 0.03%, therefore a conservative value of 1% is used. Therefore the corrected NOAEL via the dermal route is: 5083*(6/8)*0.38*(100/1) = 144866 mg/kg bw/day.
- AF for dose response relationship:
- 1
- Justification:
- A clear NOAEC was established
- AF for differences in duration of exposure:
- 1
- Justification:
- Not required as developmental toxicity is not duration-specific
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default
- AF for other interspecies differences:
- 2.5
- Justification:
- Default
- AF for intraspecies differences:
- 5
- Justification:
- Default
- AF for the quality of the whole database:
- 1
- Justification:
- Guideline, GLP study
- AF for remaining uncertainties:
- 2
- Justification:
- Additional assessment factor for use of screening data
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
There were no adverse effects in any of the available tests. However, since there is a data gap for developmental toxicity, which will be filled by testing, indicative DNELs are based on the current NOAEC for developmental toxicity from the screening study on decamethyltetrasiloxane (L4, CAS 141 -62 -8) for the purposes of initial risk characterisation.
DNELs for long-term exposure are considered adequate to protect against short-term exposures and no separate short-term DNELs are calculated.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 25 mg/m³
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 1 271 mg/m³
- Explanation for the modification of the dose descriptor starting point:
The DNEL for systemic effects via the inhalation route is determined on the basis of route-to-route extrapolation of developmental effects noted in the inhalation OECD 422 study with decamethyltetrasiloxane (141-62-8). In this study a NOAEC of at least 5083 mg/m³ was derived as there were no adverse effects up to the highest dose tested. NOAEC ≥5083mg/m³. The following correction was made to the NOAEC (inhalation): Correction for exposure duration: 6/24 (default for consumers) Therefore the corrected NOAEC is: 5083 mg/m³*(6/24) = 1271 mg/m³.
- AF for dose response relationship:
- 1
- Justification:
- A clear NOAEC was established
- AF for differences in duration of exposure:
- 1
- Justification:
- Not required as developmental toxicity is not duration-specific
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (inhalation)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default
- AF for intraspecies differences:
- 10
- Justification:
- Default
- AF for the quality of the whole database:
- 1
- Justification:
- Guideline, GLP study
- AF for remaining uncertainties:
- 2
- Justification:
- Additional assessment factor for use of screening data
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 731 mg/kg bw/day
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 146 136 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The DNEL for systemic effects via the dermal route is determined on the basis of route-to-route extrapolation of developmental effects noted in the inhalation OECD 422 study with decamethyltetrasiloxane (CAS 141-62-8). In this study a NOAEC of at least 5083 mg/m³ was derived as there were no adverse effects up to the highest dose tested. NOAEC ≥5083 mg/m³ The following correction was made to the NOAEC (inhalation) to derive a NOAEL (dermal): Correction for exposure duration: 6h / 24h (default for workers) Correction for respiratory volume: 1.15 m³/kg (default, rat). Correction for dermal penetration: based on read-across from decamethyltetrasiloxane (CAS 141-62-8) dermal penetration is approximately 0.03%, therefore a conservative value of 1% is used. Therefore the corrected NOAEL for the dermal route is: 5083*(6/24)*1.15*(100/1) = 146136 mg/kg bw/day.
- AF for dose response relationship:
- 1
- Justification:
- A clear NOAEC was established
- AF for differences in duration of exposure:
- 1
- Justification:
- Not required as developmental toxicity is not duration-specific
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default
- AF for other interspecies differences:
- 2.5
- Justification:
- Default
- AF for intraspecies differences:
- 10
- Justification:
- Default
- AF for the quality of the whole database:
- 1
- Justification:
- Guideline, GLP study
- AF for remaining uncertainties:
- 2
- Justification:
- Additional assessment factor for use of screening data
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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