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EC number: 909-129-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 October 1994 - 24 November 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 24 Februari 1987
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of m,alpha-dimethylstyrene and p,alpha-dimethylstyrene
- EC Number:
- 909-129-5
- Molecular formula:
- C10H12
- IUPAC Name:
- Reaction mass of m,alpha-dimethylstyrene and p,alpha-dimethylstyrene
- Test material form:
- liquid
- Details on test material:
- Indentification: m/p- isopropenyl toluene
Appearance: clear colourless liquid
Storage condition: room temperature
Purity: Not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Source: Charles River (UK) Ltd., Margate, Kent, U.K.
- Age at study initiation: Young adult animals (approx. 5 to 8 weeks old)
- Weight at study initiation: 131 - 154 g for females, 148 - 175 g for males
- Fasting period before study: Overnight.
- Housing: Group housing of 5 animals per cage by sex in solid floor polypropylene cages furnished with woodflakes in labeled Macrolon cages.
- Diet: Free acces to Food (Rat and Mouse Expanded Diet No.l, Special Diets services Limited, Witham, Essex, U.K.).
- Water: Free access to tap water.
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 – 21
- Humidity (%): 48 - 56
- Air changes (per hr): approx 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 17 October 1994 to 24 November 1994
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- GAVAGE METHOD: metal cannula attached to a graduated syringe.
Frequency: single dosage, on day 1.
MAXIMUM DOSE VOLUME APPLIED:
2.25 mL/kg body weight.
Specific gravity: 0.891
DOSAGE PREPARATION:
The test material was used as supplied.
Range finding study (limit test):
In a range finding study, using a dose of 2000 mg/kg body weight for 1 male and 1 female rat resulted in no deaths.
Based on this information, a dose level of 2000 mg/kg body weight was selected for the main study. - Doses:
- 2000 mg/kg body weight.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Study Design:
- Duration of observation period following administration: 14 days.
- Body weight measurements: Body weights were recorded prior to dosing and on days 7 and 14.
Observations of clinical signs and mortality: At 30 minutes, 1 hour, 2 and 4 hours after administration and thereafter once daily.
- Necropsy of survivors performed: At the end of the study the animals were killed by cervical dislocation and subjected to gross pathological examination. This consisted of an external examination and opening of the abdominal and thoracic cavities.
- Other examinations performed: none. - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- Common signs of systemic toxicity noted were ataxia, hunched posture, lethargy, pilo-erection, decreased respiratory rate and laboured respiration with incidents of loss of righting reflex and splayed gait. Animals recovered one, two or five days after dosing. Four animals showed no clinical signs throughout the study.
- Body weight:
- All animals showed expected gain in body weight during the study.
- Gross pathology:
- No abnormalities were found at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study with rats, performed according to OECD test guideline 401 and GLP principles, an LD50 >2000 mg/kg bw was determined and therefore the test item is not classified for oral toxicity according to GHS and CLP criteria.
- Executive summary:
An assessment of acute oral toxicity with m/p - Isopropenyl toluene in rats was performed according to OECD test guideline 401 and GLP principles. The test item was administered by oral gavage to 5 male and 5 female Sprague Dawley rats at 2000 mg/kg body weight. No animals died throughout the 14 days observation period. Clinical signs that were observed were ataxia, hunched posture, lethargy, pilo-erection, decreased respiratory and laboured respiration with incidents of loss of righting reflex and splayed gait. Animals recovered one, two or five days after dosing except for four animals which appeared normal throughout the study. Body weight showed the expected gain and at necroscopy assessment no abnormalities were found. An LD50 >2000 mg/kg body weight was determined for the test substance and therefore m/p - Isopropenyl toluene does not need to be classified according to CLP and GHS regulations for oral toxicity.
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