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EC number: 234-232-0 | CAS number: 10605-21-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 18, 1996 - February 1, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study already available.
Test material
- Reference substance name:
- Carbendazim
- EC Number:
- 234-232-0
- EC Name:
- Carbendazim
- Cas Number:
- 10605-21-7
- Molecular formula:
- C9H9N3O2
- IUPAC Name:
- carbendazim
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- Four to five week old male .
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal
- No. of animals per dose:
- For the main study 5 control animals and 10 test animals were used and housed in groups of 5 in the cages.
- Details on study design:
- Based on preliminary investigation, 5% w/v was selected for intradermal injection, 62.5% w/v for topical induction and 62.5 and 31.25% w/v for topical challenge.
For the main study the protocol of Magnusson & Kligman were used.
For intradermal induction, 3 pairs of injections were made into the clipped dorsal scapular region: Freund's complete adjuvant, carbendazim and a mixture of both. Six days later, the hair-freed region was treated with sodium lauryl sulphate in petrolatum to produce skin irritation. 24 hr later, a patch with carbendazim solution was applied to the skin for 48 hr. - Challenge controls:
- For challenge, flanks were clipped free of hairs and patches with carbendazim solution were applied for 24 hr.
The challenge sites were evaluated 24, 48 and 72 hr after removal of the patches and the findings were described or scored according to the usual criteria. - Positive control substance(s):
- yes
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: score after challenge
- Hours after challenge:
- 72
- Group:
- test chemical
- Dose level:
- 5% w/v for intradermal injection, 62.5% w/v for topical induction and 62.5 and 31.25% w/v for topical challenge.
- No. with + reactions:
- 4
- Total no. in group:
- 10
Any other information on results incl. tables
No signs of ill health or toxicity were reported. Body weights of animals increased.
Necrosis was seen at sites receiving Freund's complete adjuvant in test and control animals.
Slight irritation was seen in test animals and control animals receiving intradermal injections of carbendazim solution or solvent alone. Slight erythema was seen in test animals and control animals receiving dermal application of carbendazim sol. or solvent alone.
Dermal reactions were seen in four animals of the test group compared to none of the control animals. The other test animals showed no skin reactions.
Applicant's summary and conclusion
- Conclusions:
- Dermal induction and challenge induced in 4 out of 10 treated animal skin reactions indicative of sensitisation.
Based of the results of this magnusson & Kligman test, carbendazim needs classification and labelling as a skin sensitiser.
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