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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_classification-and-labelling-and-pbt-assessment.png)
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence(P, vP)
The biodegradation of this class of alkyl phosphites is expected to occur by the hydrolysis of the phosphite (abiotic degradation) into their component alcohols and then biodegradation of the alcohols. In this regard, these phosphites could generally be considered as biodegradable as their component alcohols. 2-Propylheptanol is readily biodegradable.
A biodegradation screening study, OECD 301D Closed Bottle Test, was performed by van Ginkel (2014) on TiTDP, a similar tris alkyl phosphite analog, to evaluate the persistence of TiTDP and also to compare the rate of biodegradation of TiTDP to that of its primary hydrolysis product – isotridecyl alcohol. The results of the new OECD 301D study found 57% degradation at 28 days, with degradation continuing to 63% degradation at 42 days. Whilst these results do not fully meet the ready biodegradable standard, they demonstrate that TiTDP is inherently biodegradable and not persistent. The rate of biodegradation of TiTDP is somewhat slower than that of isotridecyl alcohol, which does meet the ready criterion. This is probably due to the additional time needed for hydrolysis to occur and also for the greater sorption potential of the phosphite vs. the alcohol, which can also delay the biodegradation process.
A new OECD 301D Closed Bottle Test was performed by van Ginkel (2019) on phenyl diisodecyl phosphite, another related alkyl phosphite analog. The results found 64% degradation at 28 da and were considered to be ready biodegradable given the complex composition of the substance.
Bioaccumulation (B, vB)
Bioaccumulation concentration factor (BCF) cannot not be measured for T2PHP due to its rapid hydrolysis. Given the rapid hydrolysis of this substance, there will be little opportunity for it to bioaccumulate. Estimated BCF values for T2PHP are very low. Studies also show that the primary hydrolysis product will not bioaccumulate to any significant extent. The hydrolysis products are also readily biodegradable.
T2PHP BCF and hydrolysis product BCFs are well below the criteria for B (bioaccumulative) or vB (very bioaccumulative). As such, it is concluded that T2PHP
does not meet the criteria for B or vB.
Toxicity (T)
T2HPHP has a low order of toxicity to mammalian species. The primary effect of interest is skin sensitisation; for which it is classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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