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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 July 2016 to 22 August 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.305 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 4.3 - <= 4.5
- Details on results:
- MAIN TEST
The mean peak areas relating to the standard and sample solutions are shown in Table 1. The concentration (g/L) of test material in the sample solutions is shown in Table 2. The overall mean concentration was 0.305 g/L.
VALIDATION
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 10 to 200 mg/L. The results were satisfactory with a correlation coefficient (r) of 0.999 being obtained.
DISCUSSION
On completion of the equilibration period, the samples were clear and colourless with excess test material present. The solutions were centrifuged and the supernatants were observed to be free from excess test material with no evidence of a Tyndall beam effect.
Analysis for total organic carbon (TOC) was also performed on the sample supernatants. Results were lower than that found by LC-MS with a mean of 11.4 mg/L TOC. However, since the test material was a complex mixture, it was considered appropriate to report the higher result of 0.305 g/L by LC-MS as the definitive water solubility. - Conclusions:
- Under the conditions of this study the water solubility of the test material at 20.0 ± 0.5 °C was determined to be 0.305 g/L.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105, EU Method A.6 and OPPTS 830.7840 under GLP conditions using the flask method with liquid chromatography- mass spectroscopy.
A preliminary test was performed in order to select the appropriate method and to determine the approximate amount of test material to be used in the main test. Based on the preliminary result, mixtures of test material and purified water were added to three separate flasks. After preparation, the samples were shaken at approximately 30 °C for 24, 48 and 72 hours. After standing at 20 °C for a period of 24 hours, the contents of the flasks were centrifuged at 13 000 rpm for 15 minutes. The supernatants were observed to be free from excess test material. The pH of each solution was measured. The concentration of test material in the sample solutions was determined by LC-MS.
On completion of the equilibration period, the samples were clear and colourless with excess test material present. The solutions were centrifuged and the supernatants were observed to be free from excess test material with no evidence of a Tyndall beam effect. Following analysis, the overall mean concentration was 0.305 g/L.
Under the conditions of this study the water solubility of the test material at 20.0 ± 0.5 °C was determined to be 0.305 g/L.
Reference
Table 1: Mean peak areas of standard and sample solutions
Solution |
Mean peak area |
Standard 102 mg/L |
1.74 x 10^7 |
Standard 101 mg/L |
1.76 x 10^7 |
Sample 1A |
2.37 x 10^7 |
Sample 1B |
2.36 x 10^7 |
Sample 2A |
2.74 x 10^7 |
Sample 2B |
2.77 x 10^7 |
Sample 3A |
3.01 x 10^7 |
Sample 3B |
3.06 x 10^7 |
Standard 102 mg/L |
1.90 x 10^7 |
Standard 101 mg/L |
1.81 x 10^7 |
Table 2: Concentrations of the test material in the sample solutions.
Sample number |
Time shaken at ~ 30 ºC (hours) |
Time equilibrated at 20 ºC (hours)
|
Concentration (g/L) |
Solution pH
|
||
A |
B |
Mean |
||||
1 |
24 |
24 |
0.266 |
0.265 |
0.265 |
4.5 |
2 |
48 |
24 |
0.307 |
0.311 |
0.309 |
4.4 |
3 |
72 |
24 |
0.338 |
0.344 |
0.341 |
4.3 |
Description of key information
Under the conditions of this study the water solubility of the test material at 20.0 ± 0.5 °C was determined to be 0.305 g/L.
Key value for chemical safety assessment
- Water solubility:
- 0.305 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105, EU Method A.6 and OPPTS 830.7840 under GLP conditions using the flask method with liquid chromatography-mass spectroscopy. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
A preliminary test was performed in order to select the appropriate method and to determine the approximate amount of test material to be used in the main test. Based on the preliminary result, mixtures of test material and purified water were added to three separate flasks. After preparation, the samples were shaken at approximately 30 °C for 24, 48 and 72 hours. After standing at 20 °C for a period of 24 hours, the contents of the flasks were centrifuged at 13 000 rpm for 15 minutes. The supernatants were observed to be free from excess test material. The pH of each solution was measured. The concentration of test material in the sample solutions was determined by LC-MS.
On completion of the equilibration period, the samples were clear and colourless with excess test material present. The solutions were centrifuged and the supernatants were observed to be free from excess test material with no evidence of a Tyndall beam effect. Following analysis, the overall mean concentration was 0.305 g/L.
Under the conditions of this study the water solubility of the test material at 20.0 ± 0.5 °C was determined to be 0.305 g/L.
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