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EC number: 819-688-6 | CAS number: 219828-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Apr 2013 - 13 Jun 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- methyl 2-[(prop-2-en-1-yloxy)methyl]prop-2-enoate
- EC Number:
- 819-688-6
- Cas Number:
- 219828-90-7
- Molecular formula:
- C8H12O3
- IUPAC Name:
- methyl 2-[(prop-2-en-1-yloxy)methyl]prop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Supplier : Orient Bio Co., Ltd. 699-13, Mokdong-ri, Buk-myeon, Gapyeong-gun, Gyeonggi-do, Korea
- Number of animals and sex distinction at the time of receipt : 14 females
- A range of age and body weight at the time of receipt : 8 weeks old, 174.8 g ~ 186.2 g
- A range of age and body weight at the time of administration : 9 weeks old, 180.0g ~ 182.8 g (1st step), 181.7 g ~ 188.2 g (2nd step), 10 weeks old, 190.3 g ~ 197.1 g (3rd step)
- Housing: stainless stell cage
- Diet:ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 50 ±2 0
- Air changes (per hr): 10 - 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 mg/mL and 200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw)
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/kg bw
- Doses:
- 300, and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 4 hours after treatment and then daily for 14 days
- Frequency of observations and weighing: Body weight was measured at animal receipt day, animal allocation day, just before treatment and on day 7 and 14 after the administration. Body weight of dead animal was also measured when it was found to be dead.
- Necropsy of survivors performed: yes
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All the animals died in 3rd step(2000 mg/kg body weight), two (Animal No. : 2302, 2303) animals on day 1 and one (Animal No. : 2301) animal on day 2 after adminstration. No mortality was observed in the 1st and 2nd step (300 mg/kg body weight) groups.
- Clinical signs:
- other: Clinical signs related with the substance, the salivation, inanimation and prone position, were observed from 2 hour to day 1 in 3rd step (2000 mg/kg) dose group. No clinical signs was observed in 1st and 2nd step (300 mg/kg) groups. Clinical signs were c
- Gross pathology:
- In necropsy finding of died animals, test substance retention in the stomach were observed in all (Animal No. : 2301 ~ 2303) died animals. There were no necropsy findings caused by administration of test substance in all survived animals.
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the results, the 2-(Allyloxymethyl) acrylic acid methyl ester was classified in to GHS (Globally Harmonized Classification System for Chemical Substances and Mixtures) Category 4 (300 mg/kg body weight < LD50 < 2000 mg/kg body weight) in this study.
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