Triisononyl benzene-1,2,4-tricarboxylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1969

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Study predates Good Laborary Practices

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1969

Report date:

1969

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

Report predates GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Triisononyl benzene-1,2,4-tricarboxylate

EC Number:

258-847-9

EC Name:

Triisononyl benzene-1,2,4-tricarboxylate

Cas Number:

53894-23-8

Molecular formula:

C36H60O6

IUPAC Name:

1,2,4-tris(7-methyloctyl) benzene-1,2,4-tricarboxylate

Test material form:

liquid

Details on test material:

Production sample

Specific details on test material used for the study:

Visual description of substance was "Clear yellow, slightly viscous liquid with a faint odor."

Test animals

Species:

rat

Strain:

Sprague-Dawley

Remarks:

Described in study report as "Adult male albino rats of the Holtzman (Sprague-Dawley-derived) strain."

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

A single dose was administered by oral gavage as either the neat substance (5000 and 10000 mg/kg) or as a 3% weight per volume solution (419 and 1450 mg/kg) in corn oil. All animals were fasted three to four hours prior to dosing.

Doses:

417, 1450, 5000, and 10000 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

Rats were observed for mortality and toxic effects immediately after dosing; at one, four, and 24 hours; and once dally thereafter for a total of 14 days.
Body weights were measured initially and terminally.

Statistics:

Statistical analysis was described as "Litchfield, J. T., and Wilcoxon, F., J. Pharmacol. Exptl. Therap. 96, 99, 1949"

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD0

Effect level:

>= 10 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred at any of the tested doses.

Clinical signs:

other: At doses of 5000 or 10000 mg/kg animals showed slight depression by one hour and excessive urination and/or diarrhea. Complete recovery occurred by 48 hours (5000 mg/kg level) or Day 5 (10,000 mg/kg level)

Gross pathology:

No observable gross pathology was found

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Acute oral exposure to the test substance at doses up to 10,000 mg/kg did not result in any mortality in a 14-day post-exposure observation period. The results indicate negligible potential for acute oral toxicity.

Executive summary:

Groups of five male Sprague-Dawley rats were administered 419, 1450, 5000, or 10000 mg/kg triisononyl trimellitate by oral gavage and observed 14 days following exposure. No mortality occurred. At 5,000 and 10,000 mg/kg activity was slightly depressed one hour following exposure, with observation of excessive urination and/or diarrhea. Complete recovery was reported by 48 hours (5,000 mg/kg) or five days (10,000 mg/kg). The results indicate negligible potential for acute oral toxicity.