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EC number: 238-242-6 | CAS number: 14306-25-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 15 August 2018 to 05 September 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- OECD Guidelines for the Testing of Chemicals, Method No. 105, adopted 27. Jul. 1995: “Water Solubility “
- Deviations:
- yes
- Remarks:
- - Sampling was not performed after 1 – 3 d shaking. - Fivefold excess as proposed in the guidelines could not be used The deviations were assessed by the study director and were stated as uncritical.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Name: dermofeel PA-3 (dried)
- CAS No.: 14306-25-3
- EC No.: 238-242-6
- Source and lot/batch No.of test material: NA2253
- Appearance: white solid powder
- Production date: June 2016
- Expiration date of the lot/batch: June 2019
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: closed vessel; room temperature (20 +- 5 °C); protected from light and humidity
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- The test item was finely ground - Key result
- Water solubility:
- >= 1 163.43 - <= 1 216.41 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 2 860 g/L
- Incubation duration:
- ca. 8 d
- Temp.:
- 20 °C
- pH:
- 2
- Conclusions:
- Water solubility of the test item (OECD 105, flask method): 1189.92 ± 26.49 g/L at 20 ± 0.5°C
= 1189.92 ± 26.49 kg/m3 (SI units)
(mean value ± standard deviation of four individual vessels) - Executive summary:
The solubility of the test item in water was determined by measurement of phosphate as ingredient of the test item in the filtrated test solutions using photometer. All replicates showed good correspondence. Standard deviation of the four flasks which were used for the calculation of water solubility at the plateau was
1189.92 ± 26.49 g/L at 20.0 ± 0.5°C (OECD 105, nominal load 2.86 kg/L)
corresponding to a relative standard deviation of 2.2 %. The pH value was 2 in all four flasks, the test temperature was in the acceptable range with 19.8 – 20.5 °C over the test duration (measured in the liquid at sampling time points).
No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
Reference
Measurements during Equilibration
Visual inspection was performed during equilibration time (flask 1A-C, days 2 – 4) only. Measurements were regarded to be not necessary, because flask 1A (time 2 d) showed definitely more residue than flask 1B (time 3 d), and no residue was noticed in flask 1C (time 4 d). Equilibration was not achieved after 2 d shaking. Sampling and measurement of flasks 1A-C was performed on days 5 - 7. The data are presented in the following table:
Table Equilibration Phase
Time |
Temperature |
pH* |
Dilution |
Absorption |
Absorption |
Mean |
Mean |
Difference to |
5d |
20.3 |
2 |
40000 |
0.4782 |
0.4766 |
1.87 |
1228.19 |
- |
0.4750 |
||||||||
6d |
20.4 |
2 |
40000 |
0.4680 |
0.4658 |
1.83 |
1200.97 |
-2.2 |
0.4636 |
||||||||
7d |
20.5 |
2 |
40000 |
0.4588 |
0.4639 |
1.82 |
1196.06 |
-0.4 |
0.4689 |
* pH was tested using Tritest indicator paper Equilibration was regarded to be achieved after 5 d shaking, because no rising tendency
and no difference >15% of test item concentrations in the filtrates were detected.
Measurements at Plateau
Equilibration was regarded to be achieved after 5 d shaking, but the final measurement was performed after 8 d shaking for organizational reasons.
Table Measurements at Plateau
Time |
Temperature |
pH* |
Dilution |
Absorption |
Absorption |
Mean |
Mean |
Blank** |
- |
- |
40000 |
-0.0008 |
-0.0004 |
<0.1 |
- |
0.0000 |
|||||||
8 d |
20.3 |
2 |
40000 |
0.4576 |
0.4584 |
1.80 |
1182.20 |
0.4591 |
|||||||
8 d |
19.8 |
2 |
40000 |
0.4441 |
0.4501 |
1.77 |
1161.29 |
0.4560 |
|||||||
8 d |
20.2 |
2 |
40000 |
0.4585 |
0.4620 |
1.82 |
1191.27 |
0.4654 |
|||||||
8 d |
20.5 |
2 |
40000 |
0.4744 |
0.4753 |
1.87 |
1224.91 |
0.4762 |
* pH was tested using Tritest indicator paper
**measured after 5 d shaking
Measurements of unbounded Phosphate at Plateau
Samples were measured without digestion exemplarily only at the end of the main test in the filtrates of vessels 2 and 3 to show the determined phosphate is mainly bounded phosphate.
The results are shown in Table "Measurements at Plateau of unbounded Phosphate"
Table Measurements at Plateau of unbounded Phosphate
Time |
Dilution |
Absorption |
Absorption |
Mean |
Mean in the Filtrate |
8 d (2) |
40000 |
0.3991 |
0.3970 |
1.57 |
94.64 |
0.3949 |
|||||
8 d (3) |
40000 |
0.3553 |
0.3550 |
1.40 |
84.88 |
0.3546 |
|||||
Mean ConcentrationTest Item in the Filtrate [g/L] |
89.76 |
89.76 g/L unbounded phosphate (mean of vessels 2 and 3) corresponds to 7.5 % of the phosphate, measured after digestion. Therefore, phosphate determined after digestion during this study is mainly bounded Phosphate.
Results
The measurements of flasks 2-5 were used for the calculation of the mean.
Table Measurements used for Calculation of Solubility
Flask |
Concentration Test Item |
Total Mean |
Total Standard Deviation [g/L] |
2 |
1182.20 |
1189.92 |
26.49 |
3 |
1161.29 |
||
4 |
1191.27 |
||
5 |
1224.91 |
*RSD = relative standard deviation
Mean at the plateau is 1189.92 ± 26.49 g/L at 19.8 –20.5°C (20.0 ± 0.5°C).
Description of key information
Water solubility of the test item (OECD 105, flask method): 1189.92 ± 26.49 g/L at 20 ± 0.5°C
= 1189.92 ± 26.49 kg/m3 (SI units)
(mean value ± standard deviation of four individual vessels)
Key value for chemical safety assessment
- Water solubility:
- 1 189.92 g/L
- at the temperature of:
- 20 °C
Additional information
The solubility of the test item in water was determined by measurement of phosphate as ingredient of the test item in the filtrated test solutions using photometer. All replicates showed good correspondence. Standard deviation of the four flasks which were used for the calculation of water solubility at the plateau was
1189.92 ± 26.49 g/L at 20.0 ± 0.5°C (OECD 105, nominal load 2.86 kg/L)
corresponding to a relative standard deviation of 2.2 %. The pH value was 2 in all four flasks, the test temperature was in the acceptable range with 19.8 – 20.5 °C over the test duration (measured in the liquid at sampling time points).
No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
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