Registration Dossier
Registration Dossier
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EC number: 218-638-5 | CAS number: 2210-25-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 November 2017 - 30 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Remarks:
- shake flask method
- Specific details on test material used for the study:
- Batch/Lot number: 2161004
Appearance: White to light yellow flakes
Purity: 99.41%
Expiry date: 31 January 2018
Storage conditions: Controlled room temperature (15-25°C, below 70RH%), protected from light
Safety Precautions: Routine safety precautions (lab coat, gloves, safety glasses and face mask) for unknown materials were applied to assure personnel health and safety. - Key result
- Water solubility:
- 212 other: mg/mL
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 9.01 - <= 9.1
- Details on results:
- pH of the samples varied in the range of 9.01 – 9.10.
Samples were analysed with the above HPLC method.
Based on the measured concentrations the test mixtures were homogeneous. - Conclusions:
- In conclusion, the water solubility of NIPAM was determined to be 212 ± 8.56 mg/mL (95% confidence interval) at 20 ± 0.5°C using the shake-flask method.
- Executive summary:
In the course of this study the water solubility of NIPAM was measured using shake flask method.
The measured water solubility is 212 ± 8.56 mg/mL (95% confidence interval) at 20 ± 0.5°C.
Reference
Results of the determination of test item concentrations
Measured concentration after 24 hours (mg/mL) |
pH |
Measured concentration after 48 hours (mg/mL) |
pH |
Measured concentration after 72 hours (mg/mL) |
pH |
Solubility of the test item (mg/mL) |
210 |
9.08 |
205 |
9.01 |
208 |
9.10 |
212±8.56 |
206 |
9.07 |
208 |
9.04 |
233 |
9.08 |
|
206 |
9.06 |
205 |
9.06 |
230 |
9.07 |
|
Mean: 207 |
- |
Mean: 206 |
- |
Mean: 224 |
- |
RSD%=5.2 |
Description of key information
In the course of this study the water solubility of NIPAM was measured using shake flask method.
The measured water solubility is 212 ± 8.56 mg/mL (95% confidence interval) at 20 ± 0.5°C.
Key value for chemical safety assessment
- Water solubility:
- 0.213 mg/L
- at the temperature of:
- 20 °C
Additional information
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