Registration Dossier
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EC number: 948-073-6 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 February 2018 to 29 August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Physical Form: Brown viscous liquid to paste
- Purity: 99.9 % - Analytical method:
- other: liquid chromatography mass spectrometry
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.81
- Remarks on result:
- other: Component 1
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.05
- Remarks on result:
- other: Component 2
- Conclusions:
- The partition coefficient (LogPow) of the test substance has been determined to be 1.81 for Component 1 (m/z 127) and 3.05 for Component 2 (m/z 262).
- Executive summary:
In a study performed to the standardised guideline EU Test Method A.8 under GLP conditions, the partition coefficient (LogPow) of the test substance has been determined to be 1.81 for Component 1 (m/z 127) and 3.05 for Component 2 (m/z 262).
Reference
Summary of Results
Test |
Solubility in n-Octanol (mg/L) |
Solubility in Water (mg/L) |
LogPow |
m/z 127 Test 1 |
28756 |
414 |
1.84 |
m/z 127 Test 2 |
23935 |
403 |
1.77 |
m/z 127 Mean |
26346 |
409 |
1.81 |
m/z 262 Test 1 |
67311 |
52.07 |
3.11 |
m/z 262 Test 2 |
56507 |
57.93 |
2.99 |
m/z 262 Mean |
61909 |
55.0 |
3.05 |
Description of key information
In a study performed to the standardised guideline EU Test Method A.8 under GLP conditions, the partition coefficient (LogPow) of the test material has been determined to be 1.81 for Component 1 (m/z 127) and 3.05 for Component 2 (m/z 262) (Intertek, 2018).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
