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Diss Factsheets
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EC number: 234-909-0 | CAS number: 12039-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tungsten disilicide
- EC Number:
- 234-909-0
- EC Name:
- Tungsten disilicide
- Cas Number:
- 12039-88-2
- Molecular formula:
- Si2W
- IUPAC Name:
- Tungsten disilicide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- cattle
Test system
- Vehicle:
- other: corn oil
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- 750 μL tungsten disilicide (suspension) at 20% (w/v) concentration in corn oil.
- Duration of treatment / exposure:
- Post application the corneas were incubated for approximately 4 h at 32 ºC.
- Number of animals or in vitro replicates:
- Four sets each consisting of three corneas were tested.
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- 0.4
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The IVIS score for the corneas treated with 750 μL tungsten disilicide (suspension) at 20% (w/v) concentration in corn oil were found to be 0.40.
Based on the results of this study, an indication of the classification for tungsten disilicide is as follows:
Classification (OECD 437) : No Category - Executive summary:
EXECUTIVE SUMMARY:This study was conducted to evaluate theocular irritancy of tungsten disilicidein compliance with the OECD437 for theBCOP test.
Four sets each consisting of three corneas were tested. The first set served as control and was treated with750 μLnormal saline. The second set served as positive control and was treated with750 μL20% (w/v) imidazole innormal saline. Test item was found to be insoluble and did not form a homogenous suspension in water. Test item formed a homogenous suspension in corn oil, so the same was selected as vehicle for the treatment.One set was treated with corn oil and served as vehicle control while other set was treated with750 μLtungsten disilicide(suspension) at 20% (w/v) concentration in corn oil.Post application the corneas were incubated for approximately 4 h at32 ºC.At the end of the incubation period reading for opacity were taken.
Post opacity reading permeability was measured by applying1 mL of fluorescein sodium solution (5 mg/mL)on to the anterior surface of the cornea and was incubated forapproximately90 min at32 ºC. At the end of the incubation period Optical Density (OD) was measured at 490 nm for the fluid collected from the posterior chamber.
The meanIn-VitroIrritancy Score(IVIS) ofnormal saline, corn oiland750 μL20% (w/v) imidazole innormal saline(positive control)treated corneaswere found to be 0.98, 1.10 and 124.17,respectively. The IVIS score for the corneas treated with750 μLtungsten disilicide(suspension) at 20% (w/v) concentration in corn oil was found to be 0.40.
Based on the results of this study, an indication of the classification fortungsten disilicideis as follows:
Classification (OECD 437) : No Category
COMPLIANCE:Signed and dated GLP and Quality Assurance statements are provided. There was no deviation from regulatory requirements.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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