Registration Dossier
Registration Dossier
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EC number: 402-480-0 | CAS number: 111850-26-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- 84/449/EWG
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 402-480-0
- EC Name:
- -
- Cas Number:
- 111850-26-1
- Molecular formula:
- C24H23ClN8O11S3.xK.yNa
- IUPAC Name:
- potassium disodium 4-({4-chloro-6-[(4-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-2-[(E)-2-[1-ethyl-6-hydroxy-4-methyl-2-oxo-5-(sulfomethyl)-1,2-dihydropyridin-3-yl]diazen-1-yl]benzene-1-sulfonate
- Details on test material:
- Nature of substance : unverdünnt
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100mg
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0.3
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0.3
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Max. score:
- 0
- Remarks on result:
- other: max level of irritation
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
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