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EC number: 620-097-9 | CAS number: 54299-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on the available data for the structurally similar read across substances and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar that of the read across substances. Therefore, 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] was estimated to be not sensitizing to skin.Comparing the above annotations with the criteria of CLP regulation,1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be classified under the category “Not Classified”.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: weight of evidence approach based on similar chemicals
- Justification for type of information:
- Weight of evidence approach based on similar chemicals
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Weight of evidence based on similar chemicals
- Principles of method if other than guideline:
- The weight of evidence report has been prepared based on the read across substances identified based on structural and functional similarity to assess the dermal sensitization potential of 1,4-phenylene bis[(4-phenoxyphenyl)-methanone].
- GLP compliance:
- not specified
- Type of study:
- other: Weight of evidence approach
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 1,4-phenylene bis[(4-phenoxyphenyl)-methanone]
- Molecular formula: C32H22O4
- Molecular weight: 470.5218 g/mol
- Smiles : c1ccc(cc1)Oc2ccc(cc2)C(=O)c3ccc(cc3)C(=O)c4ccc(cc4)Oc5ccccc5
- InChI : 1S/C32H22O4/c33-31(25-15-19-29(20-16-25)35-27-7-3-1-4-8-27)23-11-13-24(14-12-23)32(34)26-17-21-30(22-18-26)36-28-9-5-2-6-10-28/h1-22H
- Substance Type: Organic
- Physical State: Solid - Species:
- other: humans, guinea pigs
- Strain:
- not specified
- Sex:
- male/female
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: petrolatum, corn oil
- Concentration / amount:
- Intradermal - 0.05 mL intradermal injection of 5% test chemical in corn oil or 50% test chemical in aqueous Freund's Adjuvant
Epicutaneous - 0.1 mL of 2.5% test chemical - Day(s)/duration:
- 24 hours
- Adequacy of induction:
- not specified
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 5% in water
- Day(s)/duration:
- 10 application
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 0.1 mL of 2.5% test chemical in petrolatum
- Day(s)/duration:
- 24 hours
- Adequacy of challenge:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 5% in water
- Day(s)/duration:
- 24 hours
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 1. 10 female guinea pigs
2. 50 human subjects - Details on study design:
- The study is based on weight of evidence approach from the read across values
- Challenge controls:
- no data available
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Clinical observations:
- no signs of sensitization observed
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- Based on the available data for the structurally similar read across substances and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar that of the read across substances. Therefore, 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] was estimated to be not sensitizing to skin.Comparing the above annotations with the criteria of CLP regulation,1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be classified under the category “Not Classified”.
- Executive summary:
Based on the available studies for the structurally similar read across chemicals, weight of evidence approach was applied to determine the extent of dermal sensitization caused by 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] in living organisms.
Kligman Maximization was performed to determine the dermal sensitization potential of the similar test chemical.
A 0.05 mL intradermal injection of 5% test chemical in corn oil or 50% test chemical in aqueous Freund's Adjuvant was administered to the shaved back of each of ten female albino guinea pigs per solution. Seven days following injection, a topical booster patch containing 10% test chemical in petrolatum was applied for 48 hours. After a rest period of 14 days, a challenge test of 0.1 mL of 2.5% test chemical in petrolatum was applied under an occlusive patch to a virgin site for 24 hours. Sites were scored 24 and 48 hours after patch removal.
No known evidence of skin sensitization was observed in treated guinea pigs after challenge exposure.
Hence, the test chemical was considered to be not sensitizing to skin.
This is supported by the results of a human repeated insult patch test conducted on 50 subjects to assess the contact sensitization caused by the similar test chemical under occlusive condition.
Induction was carried out at a dose of 5% in water on Mondays, Wednesdays and Fridays, total 10 applications were made. After 24 hours patches were removed and skin sits were scored for primary irritation. After a rest period of 10-14 days, a challenge patch was applied (to the same site, an adjacent site or both). After 24 hours the patches were removed and the sites were examined for reactions immediately and 24 and 48 hours later. Since there was no evidence of any contact sensitization, the chemical was considered to be not sensitizing on skin of human subjects.
Based on the available data for the structurally similar read across substances and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar that of the read across substances. Therefore, 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] was estimated to be not sensitizing to skin.Comparing the above annotations with the criteria of CLP regulation,1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be classified under the category “Not Classified”.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Based on the available studies for the structurally similar read across chemicals, weight of evidence approach was applied to determine the extent of dermal sensitization caused by 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] in living organisms.
Kligman Maximization was performed to determine the dermal sensitization potential of the similar test chemical.
A 0.05 mL intradermal injection of 5% test chemical in corn oil or 50% test chemical in aqueous Freund's Adjuvant was administered to the shaved back of each of ten female albino guinea pigs per solution. Seven days following injection, a topical booster patch containing 10% test chemical in petrolatum was applied for 48 hours. After a rest period of 14 days, a challenge test of 0.1 mL of 2.5% test chemical in petrolatum was applied under an occlusive patch to a virgin site for 24 hours. Sites were scored 24 and 48 hours after patch removal.
No known evidence of skin sensitization was observed in treated guinea pigs after challenge exposure.
Hence, the test chemical was considered to be not sensitizing to skin.
This is supported by the results of a human repeated insult patch test conducted on 50 subjects to assess the contact sensitization caused by the similar test chemical under occlusive condition.
Induction was carried out at a dose of 5% in water on Mondays, Wednesdays and Fridays, total 10 applications were made. After 24 hours patches were removed and skin sits were scored for primary irritation. After a rest period of 10-14 days, a challenge patch was applied (to the same site, an adjacent site or both). After 24 hours the patches were removed and the sites were examined for reactions immediately and 24 and 48 hours later. Since there was no evidence of any contact sensitization, the chemical was considered to be not sensitizing on skin of human subjects.
Based on the available data for the structurally similar read across substances and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar that of the read across substances. Therefore, 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] was estimated to be not sensitizing to skin.Comparing the above annotations with the criteria of CLP regulation,1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be classified under the category “Not Classified”.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The results of the experimental studies from the structurally similar read across substances indicate a possibility that 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be not sensitizing to skin.
Hence by applying the weight of evidence approach, 1,4-phenylene bis[(4-phenoxyphenyl)-methanone] can be considered to be not sensitizing to skin. It can be classified under the category “Not Classified” as per CLP regulation.
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