Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-401-6 | CAS number: 10141-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from sds
Data source
Reference
- Reference Type:
- other: sds
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Potassium sulfate
- EC Number:
- 231-915-5
- EC Name:
- Potassium sulfate
- Cas Number:
- 7778-80-5
- Molecular formula:
- H2O4S.2K
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: no data
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Exposure time for Male is 28 days
Exposure time for female is 53 days - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposure time for Male is 28 days
Exposure time for female is 53 days - Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- NO DATA
- Positive control:
- NO DATA
Examinations
- Parental animals: Observations and examinations:
- NO ADVERSE SYSTEMIC EFFECTS OBSERVED
- Oestrous cyclicity (parental animals):
- NO ADVERSE SYSTEMIC EFFECTS OBSERVED
- Sperm parameters (parental animals):
- NO ADVERSE SYSTEMIC EFFECTS OBSERVED
- Litter observations:
- NO ADVERSE SYSTEMIC EFFECTS OBSERVED
- Postmortem examinations (parental animals):
- NO DATA
- Postmortem examinations (offspring):
- NO DATA
- Statistics:
- NO DATA
- Reproductive indices:
- NO DATA
- Offspring viability indices:
- NO DATA
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- no effects observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Other effects:
- no effects observed
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- no effects observed
- Reproductive function: sperm measures:
- no effects observed
- Reproductive performance:
- no effects observed
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 500 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- clinical signs
- Remarks on result:
- other: Generation: NO DATA (migrated information)
Results: P1 (second parental generation)
Effect levels (P1)
- Dose descriptor:
- other:
- Effect level:
- other:
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: not determined
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- not specified
- Mortality / viability:
- not specified
- Body weight and weight changes:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
Details on results (F1)
Effect levels (F1)
- Dose descriptor:
- other: not determined
- Generation:
- other: not determined
- Effect level:
- other: Not determined
- Based on:
- other: not determined
- Sex:
- not specified
- Basis for effect level:
- other: not determined
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Target system / organ toxicity (F1)
- Critical effects observed:
- not specified
- System:
- other: not determined
- Organ:
- other: not determined
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- other: not determined
- Generation:
- other:
- Effect level:
- other: not determined
- Based on:
- other: not determined
- Remarks:
- not determined
- Sex:
- not specified
- Basis for effect level:
- other: not determined
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Target system / organ toxicity (F2)
- Critical effects observed:
- not specified
- System:
- other: not determined
- Organ:
- other:
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NO ADVERSE SYSTEMIC EFFECTS
- Executive summary:
NO ADVERSE SYSTEMIC EFFECTS
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.