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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 607-097-4 | CAS number: 225234-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- September 2, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: HET-CAM test
- Version / remarks:
- The test is a modification of that described by Kemper and Luepke (1986, FD Chem. Toxic. 24, p.495-496).
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Fats and Glyceridic oils, shea butter, unsaponifiable fraction
- EC Number:
- 607-097-4
- Cas Number:
- 225234-14-0
- Molecular formula:
- UVCB substance
- IUPAC Name:
- Fats and Glyceridic oils, shea butter, unsaponifiable fraction
Constituent 1
- Specific details on test material used for the study:
- Lipex Shea Tris, 50% in Akosun Batch P10-16-2-A
Test animals / tissue source
- Species:
- other: chick embryo
- Strain:
- other: White Leghorn eggs
Test system
- Vehicle:
- physiological saline
- Controls:
- yes
- Amount / concentration applied:
- 0.3 ml or 0.3 g.
- Duration of treatment / exposure:
- 2 and 5 mins
- Duration of post- treatment incubation (in vitro):
- 30 seconds,2 and 5 minutes
- Number of animals or in vitro replicates:
- 4 CAMs
- Details on study design:
- Please see the attached study report.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation parameter:
- other: Hyperemia
- Value:
- >= 1 - <= 5
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Minimal hemorrhage (feathering)
- Value:
- >= 3 - < 7
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- no indication of irritation
- Remarks:
- slight irritation first but then disappeared
- Irritation parameter:
- other: Hemorrhage (obvious leakage)
- Value:
- >= 5 - <= 9
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Coagulation and/or thrombosis)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this test, the results indicated that Lipex Shea Tris, 50% in Akosun Batch P10-16-2-A, at twice the submitted concentration, would have practically no ocular irritation potential in ex vivo.
- Executive summary:
Under the conditions of this test, the results indicated that Lipex Shea Tris, 50% in Akosun Batch P10-16-2-A, at twice the submitted concentration, would have practically no ocular irritation potential in ex vivo.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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